Abstract Background Circulating tumor DNA (ctDNA) isolated from plasma contains genetic
mutations that can be representative of those found in primary tumor tissue DNA. These …

Recent studies have reported germline CDH1 mutations in cases of lobular breast cancer
(LBC) not associated with the classical hereditary diffuse gastric cancer syndrome. A …

Two types of gastric adenocarcinoma can be distinguished histopathologically: the diffuse
and the intestinal type. Molecular pathology supports this theory by showing differences in …

Background Germline pathogenic variants in the E-cadherin gene (CDH1) are strongly
associated with the development of hereditary diffuse gastric cancer. There is a paucity of …

CDH1 mutation carriers have a strongly increased risk of developing gastric cancer (GC)
and lobular breast cancer (LBC). Clinical data of GC cases and surgical and histological …

Abstract The International Gastric Cancer Linkage Consortium (IGCLC) predicted that up to
25% of families fulfilling the criteria for hereditary diffuse gastric cancer (HDGC) would …

Hereditary diffuse gastric cancer is a rare autosomal dominant cancer susceptibility
syndrome caused by germline E-cadherin (CDH1) mutations in 40% of cases with a high …

Purpose: To identify germ line CDH1 mutations in hereditary diffuse gastric cancer (HDGC)
families and develop guidelines for management of at risk individuals. Experimental Design …

E-cadherin plays a major role in cell–cell adhesion and inactivating germline mutations in its
encoding gene predispose to hereditary diffuse gastric cancer. Evidence indicates that aside …

Background. An autosomal dominant syndrome of diffuse gastric cancer has been reported
with germline mutations in the E-cadherin (CDH1) gene and has been identified in …