Abstract Hereditary Diffuse Gastric Cancer (HDGC) is a cancer predisposing syndrome
mainly caused by germline inactivating variants in CDH1, encoding E-cadherin. Early-onset …

Background The frequency of E-cadherin germline mutations in countries with different
incidence rates for gastric carcinoma has not been well established. The goal of this study …

Objective (s): Gastric cancer is the first and second leading cause of cancer related death in
Iranian men and women, respectively. Gastric cancer management is based on the surgery …

Gastric cancer incidence is declining. However, it is too early to consider this neoplastic
disease as rare and the worldwide mortality rate still remains high. Several risk factors have …

E-cadherin (CDH1 gene) germline mutations are associated with the development of diffuse
gastric cancer in the context of the so-called hereditary diffuse gastric syndrome, and with an …

Background & Aims Germline mutations in the cadherin 1, type 1, E-cadherin gene (CDH1)
cause a predisposition to gastric cancer. We evaluated the ability of the internationally …

Importance The E-cadherin gene, CDH1, and the α-E-catenin gene, CTNNA1, were
previously identified as hereditary diffuse gastric cancer (HDGC) susceptibility genes …

BACKGROUND The CDH1 gene encodes E‐cadherin, an epithelial cell adhesion molecule.
Germline CDH1 mutations recently were identified in families with hereditary diffuse gastric …

An appreciable number of patients with gastric cancer have an underlying hereditary cancer
susceptibility syndrome as the cause of their gastric cancer, particularly those with early …

Hereditary diffuse gastric cancer (HDGC) is caused by germline E‐cadherin (CDH1)
mutations in 25–40% of tested families. Management options for asymptomatic mutation …