Gastric cancer is a global public health concern, ranking as the fourth leading cause of
cancer mortality, with a 5-year survival of only 20%. Approximately 10% of gastric cancers …

Gastric cancer is one of the major causes of cancer-related death worldwide. Familial
clustering is observed in about 10% of cases; 1–3% of cases are hereditary. In the latter …

Importance Hereditary cancer risk is informed by the presence of a germline gene variant
more so than by family history of cancer. Objective To assess gastric cancer risk among …

Gastric cancer is a heterogeneous and highly prevalent disease, being the fourth most
common cancer and the second leading cause of cancer associated death worldwide. Most …

Microsatellite instability (MSI) is a major pathway involved in gastric carcinogenesis
occurring in 20% of gastric cancer (GC). However, it is not clear whether MSI phenotype …

Tumour risk syndromes (TRS) are characterized by an increased risk of early-onset cancers
in a familial context. High cancer risk is mostly driven by loss-of-function variants in a single …

Although the majority of gastric carcinomas are sporadic, approximately 10% show familial
aggregation, and a hereditary cause is determined in 1%–3% cases. Of these, hereditary …

DNA and sera from 130 cases of gastric cancer and 263 population-based controls were
analyzed to study the association of HLA class II DR-DQ alleles with Helicobacter pylori (Hp) …

The management of hereditary diffuse-type gastric cancer revolves around surveillance
biopsies and the timing of prophylactic gastrectomy. In the absence of a validated …

Desmoglein-2 (Dsg2) is one of the components of the cell–cell adherence junction. We
previously reported that loss of heterozygosity at chromosome 18q12, on which the Dsg2 …