Myeloid cells, comprised of macrophages, dendritic cells, monocytes, and granulocytes,
represent a major component of the tumor microenvironment (TME) and are critically …

Tumor-associated macrophages (TAMs) are present in almost all solid tumor tissues.
16They play critical roles in immune regulation, tumor angiogenesis, tumor stem cell …

Exposure to cadmium (Cd), a non-essential heavy metal, leads to the malignant
transformation of urothelial cells and promotes bladder cancer (BC) development, but the …

Objectives Nicotine is an ingredient of tobacco, and exposure to nicotine increases the risks
of various cancers, including oral cancer. Previous studies have focused on the addictive …

Lymphatic invasion (LI) is extremely aggressive and induces worse prognosis among
patients with colorectal cancer (CRC). Thus, it is critical to characterize the cellular and …

SPP1+ macrophages have been identified as key players in the colorectal cancer (CRC)
tumor microenvironment, but their function remains unclear. This study integrated single-cell …

Background Increasing evidence indicates that the immune response plays a critical role in
the development of head and neck cancer (HNC). We aimed to develop an immune-related …

Background Arecoline, the main component of betel nut, induces malignant transformation
of oral cells through complicated unclear mechanisms. Thus, we aimed to screen the key …

Objective To explore dermatomyositis signature genes as potential biomarkers of
hepatocellular carcinoma and their associated molecular regulatory mechanisms. Methods …

Accumulating single-cell studies suggest that SPP1+ macrophages are key players in the
tumor microenvironment. However, a systematic investigation of SPP1+ macrophages in …