Antibiotic resistance in Pseudomonas aeruginosa biofilms: towards the development of novel anti-biofilm therapies

PK Taylor, ATY Yeung, REW Hancock - Journal of biotechnology, 2014 - Elsevier
The growth of bacteria as structured aggregates termed biofilms leads to their protection
from harsh environmental conditions such as physical and chemical stresses, shearing …

Pseudomonas aeruginosa biofilm infections: community structure, antimicrobial tolerance and immune response

M Rybtke, LD Hultqvist, M Givskov… - Journal of molecular …, 2015 - Elsevier
Studies of biopsies from infectious sites, explanted tissue and medical devises have
provided evidence that biofilms are the underlying cause of a variety of tissue-associated …

Pseudomonas aeruginosa biofilm: potential therapeutic targets

G Sharma, S Rao, A Bansal, S Dang, S Gupta… - Biologicals, 2014 - Elsevier
Pseudomonas aeruginosa is a gram-negative pathogen that has become an important
cause of infection, especially in patients with compromised host defense mechanisms. It is …

Matrix exopolysaccharides; the sticky side of biofilm formation

E Maunders, M Welch - FEMS microbiology letters, 2017 - academic.oup.com
Abstract The Gram-negative pathogen Pseudomonas aeruginosa is found ubiquitously
within the environment and is recognised as an opportunistic human pathogen that …

Biofilm formation in the 96-well microtiter plate

BM Coffey, GG Anderson - Pseudomonas methods and protocols, 2014 - Springer
The microtiter plate (also called 96-well plate) assay for studying biofilm formation is a
method which allows for the observation of bacterial adherence to an abiotic surface. In this …

[HTML][HTML] The Pseudomonas aeruginosa Transcriptome in Planktonic Cultures and Static Biofilms Using RNA Sequencing

A Dötsch, D Eckweiler, M Schniederjans… - PloS one, 2012 - journals.plos.org
In this study, we evaluated how gene expression differs in mature Pseudomonas aeruginosa
biofilms as opposed to planktonic cells by the use of RNA sequencing technology that gives …

[HTML][HTML] Evaluation of antimicrobial resistance, biofilm forming potential, and the presence of biofilm-related genes among clinical isolates of Pseudomonas …

E Kamali, A Jamali, A Ardebili, F Ezadi, A Mohebbi - BMC research notes, 2020 - Springer
Objectives Pseudomonas aeruginosa is known as a leading cause of nosocomial infections
worldwide. Antimicrobial resistance and biofilm production, as two main virulence factors of …

Challenges and opportunities of pH in chronic wounds

LA Wallace, L Gwynne, T Jenkins - Therapeutic delivery, 2019 - Taylor & Francis
Regarded as a silent epidemic, chronic wounds are a global public health issue. Wound
healing is a complex, synchronized cascade of physiological processes restoring the …

The power of touch: type 4 pili, the von Willebrand a domain, and surface sensing by Pseudomonas aeruginosa

SS Webster, GCL Wong, GA O'Toole - Journal of Bacteriology, 2022 - Am Soc Microbiol
Most microbes in the biosphere are attached to surfaces, where they experience mechanical
forces due to hydrodynamic flow and cell-to-substratum interactions. These forces likely …

[HTML][HTML] Nutrient Sensing and Biofilm Modulation: The Example of L-arginine in Pseudomonas

C Scribani Rossi, L Barrientos-Moreno… - International Journal of …, 2022 - mdpi.com
Bacterial biofilm represents a multicellular community embedded within an extracellular
matrix attached to a surface. This lifestyle confers to bacterial cells protection against hostile …