PANTHER: Making genome‐scale phylogenetics accessible to all

PD Thomas, D Ebert, A Muruganujan… - Protein …, 2022 - Wiley Online Library
Phylogenetics is a powerful tool for analyzing protein sequences, by inferring their
evolutionary relationships to other proteins. However, phylogenetics analyses can be …

Toward explainable artificial intelligence for precision pathology

F Klauschen, J Dippel, P Keyl… - Annual Review of …, 2024 - annualreviews.org
The rapid development of precision medicine in recent years has started to challenge
diagnostic pathology with respect to its ability to analyze histological images and …

The next-generation Open Targets Platform: reimagined, redesigned, rebuilt

D Ochoa, A Hercules, M Carmona… - Nucleic acids …, 2023 - academic.oup.com
Abstract The Open Targets Platform (https://platform. opentargets. org/) is an open source
resource to systematically assist drug target identification and prioritisation using publicly …

cGAS–STING drives the IL-6-dependent survival of chromosomally instable cancers

C Hong, M Schubert, AE Tijhuis, M Requesens… - Nature, 2022 - nature.com
Chromosomal instability (CIN) drives cancer cell evolution, metastasis and therapy
resistance, and is associated with poor prognosis. CIN leads to micronuclei that release …

HMDB 5.0: the human metabolome database for 2022

DS Wishart, AC Guo, E Oler, F Wang… - Nucleic acids …, 2022 - academic.oup.com
Abstract The Human Metabolome Database or HMDB (https://hmdb. ca) has been providing
comprehensive reference information about human metabolites and their associated …

The reactome pathway knowledgebase 2022

M Gillespie, B Jassal, R Stephan, M Milacic… - Nucleic acids …, 2022 - academic.oup.com
Abstract The Reactome Knowledgebase (https://reactome. org), an Elixir core resource,
provides manually curated molecular details across a broad range of physiological and …

Single-nucleus profiling of human dilated and hypertrophic cardiomyopathy

M Chaffin, I Papangeli, B Simonson, AD Akkad, MC Hill… - Nature, 2022 - nature.com
Heart failure encompasses a heterogeneous set of clinical features that converge on
impaired cardiac contractile function, and presents a growing public health concern …

Majorbio Cloud: A one‐stop, comprehensive bioinformatic platform for multiomics analyses

Y Ren, G Yu, C Shi, L Liu, Q Guo, C Han, D Zhang… - IMeta, 2022 - Wiley Online Library
The rapid developments of high‐throughput sequencing technology in the last decade
allowed the emergence of multiomics analyses. Analytic platforms for high‐throughput omics …

[HTML][HTML] Effective drug combinations in breast, colon and pancreatic cancer cells

P Jaaks, EA Coker, DJ Vis, O Edwards, EF Carpenter… - Nature, 2022 - nature.com
Combinations of anti-cancer drugs can overcome resistance and provide new treatments,.
The number of possible drug combinations vastly exceeds what could be tested clinically …

Senescence atlas reveals an aged-like inflamed niche that blunts muscle regeneration

V Moiseeva, A Cisneros, V Sica, O Deryagin, Y Lai… - Nature, 2023 - nature.com
Tissue regeneration requires coordination between resident stem cells and local niche
cells,. Here we identify that senescent cells are integral components of the skeletal muscle …