PANTHER: Making genome‐scale phylogenetics accessible to all
PD Thomas, D Ebert, A Muruganujan… - Protein …, 2022 - Wiley Online Library
Phylogenetics is a powerful tool for analyzing protein sequences, by inferring their
evolutionary relationships to other proteins. However, phylogenetics analyses can be …
evolutionary relationships to other proteins. However, phylogenetics analyses can be …
Toward explainable artificial intelligence for precision pathology
The rapid development of precision medicine in recent years has started to challenge
diagnostic pathology with respect to its ability to analyze histological images and …
diagnostic pathology with respect to its ability to analyze histological images and …
The next-generation Open Targets Platform: reimagined, redesigned, rebuilt
Abstract The Open Targets Platform (https://platform. opentargets. org/) is an open source
resource to systematically assist drug target identification and prioritisation using publicly …
resource to systematically assist drug target identification and prioritisation using publicly …
cGAS–STING drives the IL-6-dependent survival of chromosomally instable cancers
Chromosomal instability (CIN) drives cancer cell evolution, metastasis and therapy
resistance, and is associated with poor prognosis. CIN leads to micronuclei that release …
resistance, and is associated with poor prognosis. CIN leads to micronuclei that release …
HMDB 5.0: the human metabolome database for 2022
DS Wishart, AC Guo, E Oler, F Wang… - Nucleic acids …, 2022 - academic.oup.com
Abstract The Human Metabolome Database or HMDB (https://hmdb. ca) has been providing
comprehensive reference information about human metabolites and their associated …
comprehensive reference information about human metabolites and their associated …
The reactome pathway knowledgebase 2022
Abstract The Reactome Knowledgebase (https://reactome. org), an Elixir core resource,
provides manually curated molecular details across a broad range of physiological and …
provides manually curated molecular details across a broad range of physiological and …
Single-nucleus profiling of human dilated and hypertrophic cardiomyopathy
Heart failure encompasses a heterogeneous set of clinical features that converge on
impaired cardiac contractile function, and presents a growing public health concern …
impaired cardiac contractile function, and presents a growing public health concern …
Majorbio Cloud: A one‐stop, comprehensive bioinformatic platform for multiomics analyses
Y Ren, G Yu, C Shi, L Liu, Q Guo, C Han, D Zhang… - IMeta, 2022 - Wiley Online Library
The rapid developments of high‐throughput sequencing technology in the last decade
allowed the emergence of multiomics analyses. Analytic platforms for high‐throughput omics …
allowed the emergence of multiomics analyses. Analytic platforms for high‐throughput omics …
[HTML][HTML] Effective drug combinations in breast, colon and pancreatic cancer cells
P Jaaks, EA Coker, DJ Vis, O Edwards, EF Carpenter… - Nature, 2022 - nature.com
Combinations of anti-cancer drugs can overcome resistance and provide new treatments,.
The number of possible drug combinations vastly exceeds what could be tested clinically …
The number of possible drug combinations vastly exceeds what could be tested clinically …
Senescence atlas reveals an aged-like inflamed niche that blunts muscle regeneration
Tissue regeneration requires coordination between resident stem cells and local niche
cells,. Here we identify that senescent cells are integral components of the skeletal muscle …
cells,. Here we identify that senescent cells are integral components of the skeletal muscle …