The measurement of vascular function in isolated vessels has revealed important insights
into the structural, functional, and biomechanical features of the normal and diseased …

Abstract The nucleotide adenosine 5′-triphosphate (ATP) has classically been considered
the cell's primary energy currency. Importantly, a novel role for ATP as an extracellular …

Abstract Pannexin-1 (Panx1) channels have been shown to regulate leukocyte trafficking
and tissue inflammation but the mechanism of Panx1 in chronic vascular diseases like …

Both purinergic signaling through nucleotides such as ATP (adenosine 5′-triphosphate)
and noradrenergic signaling through molecules such as norepinephrine regulate vascular …

Ischemia-reperfusion (I/R) injury (IRI), which involves inflammation, vascular permeability,
and edema, remains a major challenge after lung transplantation. Pannexin-1 (Panx1) …

Rationale: Resistant hypertension is a major health concern with unknown cause.
Spironolactone is an effective antihypertensive drug, especially for patients with resistant …

It has become increasingly clear that the accumulation of proteins in specific regions of the
plasma membrane can facilitate cellular communication. These regions, termed signaling …

Rationale: Increasing prevalence of obesity and its associated risk with cardiovascular
diseases demands a better understanding of the contribution of different cell types within this …

Endothelial nitric oxide synthase (eNOS, NOS3) is responsible for producing nitric oxide
(NO)—a key molecule that can directly (or indirectly) act as a vasodilator and anti …

Pannexin 1 (PANX1)-mediated ATP release in vascular smooth muscle coordinates α1-
adrenergic receptor (α1-AR) vasoconstriction and blood pressure homeostasis. We recently …