Fluorine-containing drugs approved by the FDA in 2021
J He, Z Li, G Dhawan, W Zhang, AE Sorochinsky… - Chinese Chemical …, 2023 - Elsevier
Nine new fluorine-containing drugs have been approved by the US Food and Drug
Administration (FDA) in 2021, which are presented in this review article. These small …
Administration (FDA) in 2021, which are presented in this review article. These small …
[HTML][HTML] New halogen-containing drugs approved by FDA in 2021: An overview on their syntheses and pharmaceutical use
This review describes the recent Food and Drug Administration (FDA)-approved drugs (in
the year 2021) containing at least one halogen atom (covalently bound). The structures …
the year 2021) containing at least one halogen atom (covalently bound). The structures …
Highlights on US FDA-approved fluorinated drugs over the past five years (2018–2022)
The objective of this review is to provide an update on the fluorine-containing drugs
approved by US Food and Drug Administration in the span of past five years (2018–2022) …
approved by US Food and Drug Administration in the span of past five years (2018–2022) …
[HTML][HTML] Fluorine-a small magic bullet atom in the drug development: perspective to FDA approved and COVID-19 recommended drugs
During the last twenty years, organic fluorination chemistry established itself as an important
tool to get a biologically active compound. This belief can be supported by the fact that every …
tool to get a biologically active compound. This belief can be supported by the fact that every …
[HTML][HTML] Chemistry and pharmacology of fluorinated drugs approved by the FDA (2016–2022)
G Shabir, A Saeed, W Zahid, F Naseer, Z Riaz… - Pharmaceuticals, 2023 - mdpi.com
Fluorine is characterized by high electronegativity and small atomic size, which provide this
molecule with the unique property of augmenting the potency, selectivity, metabolic stability …
molecule with the unique property of augmenting the potency, selectivity, metabolic stability …
Trifluoromethoxylation/trifluoromethylthiolation/trifluoro-methylselenolation strategy for the construction of heterocycles
X Wang, Z Wang, Z Li, K Sun - Chinese Chemical Letters, 2023 - Elsevier
Abstract The XCF 3 groups (X= O, S, Se) play an increasingly important role in modern
organic chemistry due to their unique electronegativity, lipophilic nature, metabolic stability …
organic chemistry due to their unique electronegativity, lipophilic nature, metabolic stability …
[HTML][HTML] Changes in tropospheric air quality related to the protection of stratospheric ozone in a changing climate
S Madronich, B Sulzberger, JD Longstreth… - Photochemical & …, 2023 - Springer
Ultraviolet (UV) radiation drives the net production of tropospheric ozone (O3) and a large
fraction of particulate matter (PM) including sulfate, nitrate, and secondary organic aerosols …
fraction of particulate matter (PM) including sulfate, nitrate, and secondary organic aerosols …
[HTML][HTML] New approved drugs appearing in the pharmaceutical market in 2022 featuring fragments of tailor-made amino acids and fluorine
The strategic fluorination of oxidatively vulnerable sites in bioactive compounds is a
relatively recent, widely used approach allowing us to modulate the stability, bio-absorption …
relatively recent, widely used approach allowing us to modulate the stability, bio-absorption …
[HTML][HTML] Anti-Counterfeiting and Traceability Consensus Algorithm Based on Weightage to Contributors in a Food Supply Chain of Industry 4.0
Supply chain management can significantly benefit from contemporary technologies. Among
these technologies, blockchain is considered suitable for anti-counterfeiting and traceability …
these technologies, blockchain is considered suitable for anti-counterfeiting and traceability …
Ligand‐Controlled Palladium‐Catalyzed Regiodivergent Defluorinative Allylation of gem‐Difluorocyclopropanes via σ‐Bond Activation
L Wu, M Wang, Y Liang, Z Shi - Chinese Journal of Chemistry, 2022 - Wiley Online Library
Comprehensive Summary Monofluoroalkenes are important and versatile privileged
components in pharmacologically relevant molecules. Here, we report a method for the …
components in pharmacologically relevant molecules. Here, we report a method for the …