Neurodegenerative diseases are common, incurable neurological disorders with high
prevalence, and lead to memory, movement, language, and intelligence impairments …

Introduction In this review, recent developments and applications with cell-penetrating
peptides (CPP) are discussed. CPPs are widely used tools for the delivery of various …

Central nervous system (CNS) diseases are among the most difficult to treat, mainly
because the vast majority of the drugs fail to cross the blood-brain barrier (BBB) or to reach …

Brain-derived neurotrophic factor (BDNF) is actively produced and utilized in cortical circuits
throughout life to sustain neuronal function and synaptic plasticity. In animal models of …

Despite the efforts of the pharmaceutical and research sectors, Alzheimer's disease (AD)
remains incurable, imposing the demand for new effective strategies. Vitamin B12 (VB12) …

The blood-brain barrier (BBB) and the blood-cerebrospinal fluid barrier (BCSF) are two of
the most complex and sophisticated concierges that defend the central nervous system …

Toxic aggregated amyloid-β accumulation is a key pathogenic event in Alzheimer's disease.
Treatment approaches have focused on the suppression, deferral, or dispersion of amyloid …

Senile plaques composed of amyloid β (Aβ) fibrils are considered the leading cause of
Alzheimer's disease (AD). Molecules with the ability to inhibit Aβ aggregation and/or …

Abstract Vgf (non-acronymic), a neurotrophin stimulated protein which plays a crucial role in
learning, synaptic activity, and neurogenesis, is markedly downregulated in the brain of …

Alzheimer's Disease (AD) is an irreversible neurodegenerative disease for which no
modifying therapies are presently available. Besides the identification of pathological …