Sepsis, a dysregulated immune response due to life-threatening organ dysfunction, caused
by drug-resistant pathogens, is a major global health threat contributing to high disease …

The incidence and prevalence of sepsis depend on the definitions and records that we use
and we may be underestimating their impact. Up to 60% of the cases come from the …

Purpose Severe community-acquired pneumonia (sCAP) is associated with high morbidity
and mortality, and whilst European and non-European guidelines are available for …

Background Cholestasis, as a main manifestation, induces liver injury during sepsis. The
farnesoid X receptor (FXR) plays an important role in regulating bile acid homeostasis …

The digitization of a patient's health record has profoundly impacted medicine and
healthcare. The compilation and accessibility of medical history has provided clinicians an …

Sepsis has no proven pharmacologic treatment other than appropriate antibiotic agents,
fluids, vasopressors as needed, and possibly corticosteroids. It is generally initiated mainly …

Septic shock is a life-threatening condition in which timely treatment substantially reduces
mortality. Reliable identification of patients with sepsis who are at elevated risk of …

Acute respiratory distress syndrome (ARDS) is driven by a severe pro-inflammatory
response resulting in lung damage, impaired gas exchange and severe respiratory failure …

Sepsis is a common condition that is associated with significant morbidity, mortality and
health-care cost. Pulmonary and non-pulmonary sepsis are common causes of the acute …

Because of its high incidence and clinical complexity, sepsis is a major challenge to
clinicians and researchers and a global burden to healthcare systems and society. Despite …