Aging is a complex and multifaceted process involving a variety of interrelated molecular
mechanisms and cellular systems. Phenotypically, the biological aging process is …

Senescence is a heterogenous and dynamic process in which various cell types undergo
cell‐cycle arrest due to cellular stressors. While senescence has been implicated in aging …

BACKGROUND: Arterial stiffening may contribute to the pathogenesis of metabolic
dysfunction–associated steatotic liver disease. We aimed to assess relations of vascular …

High-fat diets (HFDs) have pervaded modern dietary habits, characterized by their excessive
saturated fat content and low nutritional value. Epidemiological studies have compellingly …

Osteoporosis is a disease characterized by loss of bone mass, where bones become fragile
and more likely to fracture. Bone density begins to decrease at age 50, and a state of …

Aging is the greatest non-modifiable risk factor for most diseases, including cardiovascular
diseases (CVD), which remain the leading cause of mortality worldwide. Robust evidence …

Aging is a complex biological and physiological change that leads to a loss of function in all
living organisms. Although the mechanism behind the aging process is still largely unknown …

Urokinase‐type plasminogen activator (PLAU), a member of the S1 serine peptidase family
in Clan PA, plays a crucial role in the conversion of plasminogen into active plasmin …

Objectives: Considering the increase in the old adult population and age-related disorders
there is a need for strategies to reduce the complications of aging. Senolytic drugs might …

اهداف: نظر به افزایش جمعیت سالمند و بیماری های مرتبط با سالمندی در جهان، نیاز به راهکارهایی
برای کاهش عوارض پیری وجود دارد. داروهای سنولیتیک با از بین بردن سلولهای دچار پیری، عمدتا …‎