Drug discovery from natural sources

YW Chin, MJ Balunas, HB Chai, AD Kinghorn - The AAPS journal, 2006 - Springer
Organic compounds from terrestrial and marine organisms have extensive past and present
use in the treatment of many diseases and serve as compounds of interest both in their …

Can invalid bioactives undermine natural product-based drug discovery?

J Bisson, JB McAlpine, JB Friesen… - Journal of medicinal …, 2016 - ACS Publications
High-throughput biology has contributed a wealth of data on chemicals, including natural
products (NPs). Recently, attention was drawn to certain, predominantly synthetic …

Documentation of herbal medicines used for the treatment and management of human diseases by some communities in southern Ghana

AA Boadu, A Asase - Evidence‐Based Complementary and …, 2017 - Wiley Online Library
Traditional medicine is an important component of the health care system of most
developing countries. However, indigenous knowledge about herbal medicines of many …

Curcumin-loaded biodegradable polymeric micelles for colon cancer therapy in vitro and in vivo

ML Gou, K Men, HS Shi, ML Xiang, J Zhang, J Song… - Nanoscale, 2011 - pubs.rsc.org
Curcumin is an effective and safe anticancer agent, but its hydrophobicity inhibits its clinical
application. Nanotechnology provides an effective method to improve the water solubility of …

Antibacterial natural products in medicinal chemistry—exodus or revival?

F Von Nussbaum, M Brands, B Hinzen… - Angewandte Chemie …, 2006 - Wiley Online Library
To create a drug, nature's blueprints often have to be improved through semisynthesis or
total synthesis (chemical postevolution). Selected contributions from industrial and academic …

New aspects of natural products in drug discovery

KS Lam - Trends in microbiology, 2007 - cell.com
During the past 15 years, most large pharmaceutical companies have decreased the
screening of natural products for drug discovery in favor of synthetic compound libraries …

Plant-derived compounds in clinical trials

A Saklani, SK Kutty - Drug discovery today, 2008 - Elsevier
Plants remain an important source of new drugs, new drug leads and new chemical entities.
The plant-based drug discovery resulted mainly in the development of anticancer and anti …

[图书][B] Chitin, chitosan, oligosaccharides and their derivatives: biological activities and applications

SK Kim - 2010 - books.google.com
Providing comprehensive coverage of the biological activities and industrial applications of
Chitin, Chitosan, oligosaccharides, and their derivatives, this book presents a balance of …

Synthesis, reactions and application of chalcones: A systematic review

MA Shalaby, SA Rizk, AM Fahim - Organic & Biomolecular Chemistry, 2023 - pubs.rsc.org
Chalcones are a group of naturally occurring compounds that have biological effects that
include anti-inflammatory, anti-cancer, and antibacterial properties. Current chalcone …

[PDF][PDF] Natural sources as potential anti-cancer agents: A review

A Bhanot, R Sharma, MN Noolvi - International journal of phytomedicine, 2011 - core.ac.uk
Natural products remain an important source of new drugs, new drug leads and new
chemical entities. The plant based drug discovery resulted mainly in the development of …