Cancer chemotherapy with indole-3-carbinol, bis (3′-indolyl) methane and synthetic analogs

S Safe, S Papineni, S Chintharlapalli - Cancer letters, 2008 - Elsevier
Indole-3-carbinol (I3C) conjugates are phytochemicals expressed in brassica vegetables
and have been associated with the anticancer activities of vegetable consumption. I3C and …

Visible light-induced functionalization of indazole and pyrazole: a recent update

D Ghosh, S Ghosh, A Ghosh, P Pyne… - Chemical …, 2022 - pubs.rsc.org
Indazole and pyrazole are renowned as a prodigious class of heterocycles having versatile
uses in medicinal as well as industrial chemistry. Considering sustainable approaches …

[HTML][HTML] Echinatin suppresses esophageal cancer tumor growth and invasion through inducing AKT/mTOR-dependent autophagy and apoptosis

P Hong, QW Liu, Y Xie, QH Zhang, L Liao, QY He… - Cell death & …, 2020 - nature.com
Esophageal squamous cell carcinoma (ESCC) is one of the most common malignant tumors
with poor survival. It is urgent to search for new efficient drugs with good stability and safety …

Curcumin: Pharmaceutical solids as a platform to improve solubility and bioavailability

K Suresh, A Nangia - CrystEngComm, 2018 - pubs.rsc.org
Curcumin (CUR) is the prime curcuminoid in the Indian dietary spice turmeric, Curcuma
longa, a plant of the Zingiberaceae family. CUR has promising and diverse therapeutic …

A comprehensive review on β-lapachone: Mechanisms, structural modifications, and therapeutic potentials

Q Gong, J Hu, P Wang, X Li, X Zhang - European Journal of Medicinal …, 2021 - Elsevier
Abstract β-Lapachone (β-lap, 1), an ortho-naphthoquinone natural product isolated from the
lapacho tree (Tabebuia avellanedae) in many regions of South America, has received …

Challenges and opportunities in drug discovery from plants

SM Jachak, A Saklani - Current science, 2007 - JSTOR
Drug discovery from plants involves a multidisciplinary approach combining botanical,
ethnobotanical, phytochemical and biological techniques. Plants continue to provide us new …

Fifty years of drug discovery from fungi

AH Aly, A Debbab, P Proksch - Fungal Diversity, 2011 - Springer
For the past 50 years, fungal secondary metabolites have revolutionized medicine yielding
blockbuster drugs and drug leads of enormous therapeutic and agricultural potential. Since …

Underexplored opportunities for natural products in drug discovery: miniperspective

BL DeCorte - Journal of Medicinal Chemistry, 2016 - ACS Publications
The importance of natural products in the treatment of human disease is well documented.
While natural products continue to have a profound impact on human health, chemists have …

Metabolomics for bioactivity assessment of natural products

ND Yuliana, A Khatib, YH Choi… - Phytotherapy …, 2011 - Wiley Online Library
Natural products historically have been a rich source of lead molecules in drug discovery,
based on their capability to create unique and diverse chemical structures. However, it is …

Medicinal plants in light of history: recognized therapeutic modality

H Khan - Journal of evidence-based complementary & …, 2014 - journals.sagepub.com
Medicinal plants have an unbelievable history in terms of serving humanity in almost all
continents of the world. Traditional healers have transferred that incredible knowledge from …