Major achievements in bone research have always relied on animal models and in vitro
systems derived from patient and animal material. However, the use of animals in research …

Abstract Purpose of Review The integration of data from multiple genomic assays from
humans and non-human model organisms is an effective approach to identify genes …

Four tyrosine kinase inhibitors, alectinib, apatinib, lenvatinib and anlotinib, have been
shown to be effective in the treatment of clinical tumors, but their cardiac risks have also …

Osteoporosis is the most prevalent bone condition in the ageing population. This systemic
disease is characterized by microarchitectural deterioration of bone, leading to increased …

This study delves into the potential of chito-oligosaccharides (COS) to promote osteoblast
differentiation and prevent osteoporosis, utilizing experiments with mouse MSCs and the …

Bone and muscle are coupled through developmental, mechanical, paracrine, and autocrine
signals. Genetic variants at the CPED1-WNT16 locus are dually associated with bone-and …

Genetic diseases affecting the skeletal system present with a wide range of symptoms that
make diagnosis and treatment difficult. Genome‐wide association and sequencing studies …

Purpose of Review GWAS, as a largely correlational analysis, requires in vitro or in vivo
validation. Zebrafish (Danio rerio) have many advantages for studying the genetics of …

Zebrafish as a preclinical drug induced liver injury (DILI) model provides multiple
advantages ranging from ease of breeding and maintenance, availability of different strains …

Osteoporosis is a prevalent age-related disease characterised by low bone mineral density
(BMD) and fragility fractures. In the clinic there is a demand for new osteo-anabolic …