A novel organotypic cortical slice culture model for traumatic brain injury: molecular changes induced by injury and mesenchymal stromal cell secretome treatment

F Pischiutta, H Cavaleiro, E Caruso… - Frontiers in Cellular …, 2023 - frontiersin.org
Traumatic brain injury (TBI) is a major worldwide neurological disorder with no
neuroprotective treatment available. Three-dimensional (3D) in vitro models of brain …

Recovery Potential in Patients Who Died After Withdrawal of Life-Sustaining Treatment: A TRACK-TBI Propensity Score Analysis

WR Sanders, JK Barber, NR Temkin… - Journal of …, 2024 - liebertpub.com
Among patients with severe traumatic brain injury (TBI), there is high prognostic uncertainty
but growing evidence that recovery of independence is possible. Nevertheless, families are …

Recent Advances in Biomaterials‐Based Therapies for Alleviation and Regeneration of Traumatic Brain Injury

H Hu, X Chen, K Zhao, W Zheng… - Macromolecular …, 2023 - Wiley Online Library
Traumatic brain injury (TBI), a major public health problem accompanied with numerous
complications, usually leads to serve disability and huge financial burden. The adverse and …

[HTML][HTML] Stress and traumatic brain injury: An inherent bi-directional relationship with temporal and synergistic complexities

J Brand, SJ McDonald, JR Gawryluk, BR Christie… - Neuroscience & …, 2023 - Elsevier
Traumatic brain injury (TBI) and stress are prevalent worldwide and can both result in life-
altering health problems. While stress often occurs in the absence of TBI, TBI inherently …

Fluid biomarkers and neuroimaging in mild traumatic brain injury: current uses and potential future directions for clinical use in emergency medicine

V Newcombe, S Richter, DP Whitehouse… - Emergency medicine …, 2023 - emj.bmj.com
Mild traumatic brain injury is a common presentation to the emergency department, with
current management often focusing on determining whether a patient requires a CT head …

Data-driven approaches to reveal the pathobiological heterogeneity in patients with traumatic brain injury

C Åkerlund, A Ercole - Intensive care medicine, 2023 - Springer
In traumatic brain injury (TBI), the inability of the Glasgow Coma Scale (GCS) to capture the
inherent heterogeneity of the disease may provide some explanation as to why randomised …

Study protocol for investigating the clinical performance of an automated blood test for glial fibrillary acidic protein and ubiquitin carboxy-terminal hydrolase L1 blood …

A Lagares, JF Payen, P Biberthaler, MA Poca… - BMJ open, 2023 - bmjopen.bmj.com
Introduction Two blood brain-derived biomarkers, glial fibrillar acidic protein (GFAP) and
ubiquitin carboxy-terminal hydrolase L1 (UCH-L1), can rule out intracranial lesions in …

Early systemic insults following traumatic brain injury: association with biomarker profiles, therapy for intracranial hypertension, and neurological outcomes—an …

C Robba, F Graziano, E Picetti, C Åkerlund… - Intensive care …, 2024 - Springer
Purpose We analysed the impact of early systemic insults (hypoxemia and hypotension, SIs)
on brain injury biomarker profiles, acute care requirements during intensive care unit (ICU) …

Colloidal therapeutics in the management of traumatic brain injury: Portray of biomarkers and drug-targets, preclinical and clinical pieces of evidence and future …

S Arya, D Bahuguna, G Bajad, S Loharkar… - Colloids and Surfaces B …, 2023 - Elsevier
Complexity associated with the aberrant physiology of traumatic brain injury (TBI) makes its
therapeutic targeting vulnerable. The underlying mechanisms of pathophysiology of TBI are …

Blood-Based Biomarkers for Neuroprognostication in Acute Brain Injury

AM Nguyen, V Saini, HE Hinson - Seminars in neurology, 2023 - thieme-connect.com
Acute brain injury causes loss of functionality in patients that often is devastating. Predicting
the degree of functional loss and overall prognosis requires a multifaceted approach to help …