GABAergic system dysfunction in autism spectrum disorders

H Zhao, X Mao, C Zhu, X Zou, F Peng… - Frontiers in cell and …, 2022 - frontiersin.org
Autism spectrum disorder (ASD) refers to a series of neurodevelopmental diseases
characterized by two hallmark symptoms, social communication deficits and repetitive …

Neuroinflammation and cytokines in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS): a critical review of research methods

MB VanElzakker, SA Brumfield… - Frontiers in neurology, 2019 - frontiersin.org
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is the label given to a
syndrome that can include long-term flu-like symptoms, profound fatigue, trouble …

Neurometabolite levels in the brains of patients with autism spectrum disorders: A meta-analysis of proton magnetic resonance spectroscopy studies (N = 1501)

Y Du, L Chen, MC Yan, YL Wang, XL Zhong… - Molecular …, 2023 - nature.com
Evidence suggests that neurometabolite alterations may be involved in the pathophysiology
of autism spectrum disorders (ASDs). We performed a meta-analysis of proton magnetic …

Increased prefrontal GABA concentrations in adults with autism spectrum disorders

S Maier, AL Düppers, K Runge, M Dacko… - Autism …, 2022 - Wiley Online Library
The excitatory‐inhibitory imbalance hypothesis postulates dysregulation of the gamma‐
aminobutyric acid (GABA) and glutamate (Glu) neurotransmitter systems as a common …

[HTML][HTML] Drug development for autism spectrum disorder (ASD): progress, challenges, and future directions

JT McCracken, E Anagnostou, C Arango… - European …, 2021 - Elsevier
In 2017, facing lack of progress and failures encountered in targeted drug development for
Autism Spectrum Disorder (ASD) and related neurodevelopmental disorders, the ISCTM …

Concentrations of cortical GABA and glutamate in young adults with autism spectrum disorder

T Kolodny, MP Schallmo, J Gerdts… - Autism …, 2020 - Wiley Online Library
The balance of excitation and inhibition in neural circuits is hypothesized to be increased in
autism spectrum disorder, possibly mediated by altered signaling of the inhibitory …

[HTML][HTML] The contribution of [1H] magnetic resonance spectroscopy to the study of excitation-inhibition in autism

LA Ajram, AC Pereira, AMS Durieux, HE Velthius… - Progress in Neuro …, 2019 - Elsevier
Autism spectrum disorder (ASD) affects over 1: 100 of the population and costs the UK more
than£ 32bn and the USA more than $175 bn (£ 104bn) annually. Its core symptoms are …

Brain Glutathione and GABA+ levels in autistic children

Y Song, KE Hupfeld, CW Davies‐Jenkins… - Autism …, 2024 - Wiley Online Library
Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by social
communication challenges and repetitive behaviors. Altered neurometabolite levels …

Motor cortex excitation/inhibition imbalance in young adults with autism Spectrum disorder: a MRS-TMS approach

I Bernardino, A Dionísio, IR Violante, R Monteiro… - Frontiers in …, 2022 - frontiersin.org
Excitatory/inhibitory imbalance has been suggested as a neurobiological substrate of the
cognitive symptomatology in Autism Spectrum Disorder (ASD). Studies using magnetic …

Neurochemical differences in core regions of the autistic brain: a multivoxel 1H-MRS study in children

A Dionísio, A Espírito, AC Pereira, S Mouga… - Scientific Reports, 2024 - nature.com
Autism spectrum disorder (ASD) is a neurodevelopmental condition which compromises
various cognitive and behavioural domains. The understanding of the pathophysiology and …