Tumor angiogenesis and anti-angiogenic strategies for cancer treatment
Angiogenesis is the process through which novel blood vessels are formed from pre-existing
ones and it is involved in both physiological and pathological processes of the body …
ones and it is involved in both physiological and pathological processes of the body …
[HTML][HTML] New insights into the role of adipocytes in pancreatic cancer progression: paving the way towards novel therapeutic targets
Pancreatic cancer (PC) remains one of the most lethal malignancies across the world, which
is due to delayed diagnosis and resistance to current therapies. The interactions between …
is due to delayed diagnosis and resistance to current therapies. The interactions between …
SARS-CoV-2 infection-induced growth factors play differential roles in COVID-19 pathogenesis
Aims Biologically active molecules cytokines and growth factors (GFs) are critical regulators
of tissue injury/repair and emerge as key players in COVID-19 pathophysiology. However …
of tissue injury/repair and emerge as key players in COVID-19 pathophysiology. However …
Extracellular Matrix–Associated Factors Play Critical Roles in Regulating Pancreatic β-Cell Proliferation and Survival
SE Townsend, M Gannon - Endocrinology, 2019 - academic.oup.com
This review describes formation of the islet basement membrane and the function of
extracellular matrix (ECM) components in β-cell proliferation and survival. Implications for …
extracellular matrix (ECM) components in β-cell proliferation and survival. Implications for …
[HTML][HTML] Conserved regulatory motifs in the juxtamembrane domain and kinase N-lobe revealed through deep mutational scanning of the MET receptor tyrosine kinase …
GO Estevam, EM Linossi, CB Macdonald, CA Espinoza… - bioRxiv, 2023 - ncbi.nlm.nih.gov
MET is a receptor tyrosine kinase (RTK) responsible for initiating signaling pathways
involved in development and wound repair. MET activation relies on ligand binding to the …
involved in development and wound repair. MET activation relies on ligand binding to the …
[HTML][HTML] miR-532-3p promotes hepatocellular carcinoma progression by targeting PTPRT
Y Wang, Z Yang, L Wang, L Sun, Z Liu, Q Li… - Biomedicine & …, 2019 - Elsevier
Background Aberrant expression of miR-532-3p was involved in progression and
development of multiple cancers, whereas miR-532-3p has not been reported in …
development of multiple cancers, whereas miR-532-3p has not been reported in …
Regulation of energy metabolism by receptor tyrosine kinase ligands
Metabolic diseases, such as diabetes, obesity, and fatty liver disease, have now reached
epidemic proportions. Receptor tyrosine kinases (RTKs) are a family of cell surface …
epidemic proportions. Receptor tyrosine kinases (RTKs) are a family of cell surface …
Unlocking c-MET: A comprehensive journey into targeted therapies for breast cancer
Breast cancer is the most common malignancy among women, posing a formidable health
challenge worldwide. In this complex landscape, the c-MET (cellular-mesenchymal …
challenge worldwide. In this complex landscape, the c-MET (cellular-mesenchymal …
Application of hepatocyte growth factor for acute spinal cord injury: the road from basic studies to human treatment
K Kitamura, N Nagoshi, O Tsuji, M Matsumoto… - International journal of …, 2019 - mdpi.com
Hepatocyte growth factor (HGF) was first identified as a potent mitogen for mature
hepatocytes, and has also gained attention as a strong neurotrophic factor in the central …
hepatocytes, and has also gained attention as a strong neurotrophic factor in the central …
Inhibition of autocrine HGF maturation overcomes cetuximab resistance in colorectal cancer
VT Jones, R Graves-Deal, Z Cao, G Bogatcheva… - Cellular and Molecular …, 2024 - Springer
Although amplifications and mutations in receptor tyrosine kinases (RTKs) act as bona fide
oncogenes, in most cancers, RTKs maintain moderate expression and remain wild-type …
oncogenes, in most cancers, RTKs maintain moderate expression and remain wild-type …