[HTML][HTML] SOCS-JAK-STAT inhibitors and SOCS mimetics as treatment options for autoimmune uveitis, psoriasis, lupus, and autoimmune encephalitis

R Pandey, M Bakay, H Hakonarson - Frontiers in immunology, 2023 - frontiersin.org
Autoimmune diseases arise from atypical immune responses that attack self-tissue epitopes,
and their development is intricately connected to the disruption of the JAK-STAT signaling …

[HTML][HTML] Understanding Behçet's disease in the context of innate immunity activation

SF Perazzio, LEC Andrade, AWS De Souza - Frontiers in immunology, 2020 - frontiersin.org
Behçet´ s disease (BD) is a heterogeneous condition consisting of idiopathic systemic
vasculitis affecting large and small blood vessels of different types (ie, arteries, veins, or …

Behçet's disease in children: diagnostic and management challenges

G Costagliola, S Cappelli… - Therapeutics and Clinical …, 2020 - Taylor & Francis
Behçet's Disease (BD) is an inflammatory disease of unknown etiology with multisystemic
involvement, being the main clinical manifestations represented by recurrent oral and …

[HTML][HTML] Behcet's disease uveitis

M Joubert, AC Desbois, F Domont… - Journal of Clinical …, 2023 - mdpi.com
Uveitis in Behçet's disease (BD) is frequent (40% of cases) and is a major cause of
morbidity. The age of onset of uveitis is between 20 and 30 years. Ocular involvement …

Perspectives for immunotherapy in noninfectious immune mediated uveitis

S Touhami, J Gueudry, M Leclercq… - Expert Review of …, 2021 - Taylor & Francis
Introduction: Noninfectious uveitis (NIU) is one of the leading causes of blindness
worldwide. In adult patients, anterior NIU is usually managed with topical corticosteroids. In …

Behçet's disease uveitis: is there a need for new emerging drugs?

I Tugal-Tutkun, P Çakar Özdal - Expert Opinion on Emerging Drugs, 2020 - Taylor & Francis
Introduction: Behçet's disease uveitis (BDU) is a potentially blinding disorder. Systemic
treatment with disease-modifying anti-rheumatic drugs (DMARDs) is mandatory in patients …

Ocular features of the HLA-B27-positive seronegative spondyloarthropathies

G Jhaj, LJ Kopplin - Current Opinion in Ophthalmology, 2018 - journals.lww.com
Acute anterior uveitis is the most common ocular manifestation in HLA-B27 positive
seronegative spondyloarthropathies. Suspicion for HLA-B27 associated uveitis should …

[PDF][PDF] Behçet's syndrome and ocular involvement: changes over time

C Posarelli, MN Maglionico, R Talarico… - Clin Exp …, 2020 - clinexprheumatol.org
Ocular involvement in Behçet's syndrome still represents a challenge for both
rheumatologists and ophthalmologists; over the past 20 years the availability of new …

[HTML][HTML] Old and new challenges in uveitis associated with Behçet's disease

J Gueudry, M Leclercq, D Saadoun… - Journal of clinical …, 2021 - mdpi.com
Behçet's disease (BD) is a systemic vasculitis disease of unknown origin occurring in young
people, which can be venous, arterial or both, classically occlusive. Ocular involvement is …

[HTML][HTML] Shaping the future of Behçet's uveitis management: A comprehensive review of efficacy, challenges, and prospects of biologic therapies

B Li, H Li, Q Huang, Y Zheng - Ophthalmology and Therapy, 2023 - Springer
Behçet's uveitis (BU), a vision-threatening manifestation of Behçet's disease, poses
substantial management challenges due to its chronic, relapsing nature and potential for …