[HTML][HTML] Microglia states and nomenclature: A field at its crossroads
Microglial research has advanced considerably in recent decades yet has been constrained
by a rolling series of dichotomies such as" resting versus activated" and" M1 versus M2." …
by a rolling series of dichotomies such as" resting versus activated" and" M1 versus M2." …
Neutrophil phenotypes and functions in cancer: A consensus statement
Neutrophils are the first responders to infection and inflammation and are thus a critical
component of innate immune defense. Understanding the behavior of neutrophils as they …
component of innate immune defense. Understanding the behavior of neutrophils as they …
[HTML][HTML] Cross-tissue single-cell landscape of human monocytes and macrophages in health and disease
Mononuclear phagocytes (MNPs) encompass dendritic cells, monocytes, and macrophages
(MoMac), which exhibit antimicrobial, homeostatic, and immunoregulatory functions. We …
(MoMac), which exhibit antimicrobial, homeostatic, and immunoregulatory functions. We …
[HTML][HTML] Type I interferon activates MHC class I-dressed CD11b+ conventional dendritic cells to promote protective anti-tumor CD8+ T cell immunity
Tumor-infiltrating dendritic cells (DCs) assume varied functional states that impact anti-tumor
immunity. To delineate the DC states associated with productive anti-tumor T cell immunity …
immunity. To delineate the DC states associated with productive anti-tumor T cell immunity …
[HTML][HTML] Systemic vaccination induces CD8+ T cells and remodels the tumor microenvironment
F Baharom, RA Ramirez-Valdez, A Khalilnezhad… - Cell, 2022 - cell.com
Therapeutic cancer vaccines are designed to increase tumor-specific T cell immunity.
However, suppressive mechanisms within the tumor microenvironment (TME) may limit T …
However, suppressive mechanisms within the tumor microenvironment (TME) may limit T …
Beyond immune checkpoint blockade: emerging immunological strategies
The success of checkpoint inhibitors has accelerated the clinical implementation of a vast
mosaic of single agents and combination immunotherapies. However, the lack of clinical …
mosaic of single agents and combination immunotherapies. However, the lack of clinical …
cDC1 prime and are licensed by CD4+ T cells to induce anti-tumour immunity
Conventional type 1 dendritic cells (cDC1) are thought to perform antigen cross-
presentation, which is required to prime CD8+ T cells,, whereas cDC2 are specialized for …
presentation, which is required to prime CD8+ T cells,, whereas cDC2 are specialized for …
Dendritic cell regulation of T helper cells
X Yin, S Chen, SC Eisenbarth - Annual review of immunology, 2021 - annualreviews.org
As the professional antigen-presenting cells of the immune system, dendritic cells (DCs)
sense the microenvironment and shape the ensuing adaptive immune response. DCs can …
sense the microenvironment and shape the ensuing adaptive immune response. DCs can …
Immune responses to stroke: mechanisms, modulation, and therapeutic potential
C Iadecola, MS Buckwalter… - The Journal of clinical …, 2020 - Am Soc Clin Investig
Stroke is the second leading cause of death worldwide and a leading cause of disability.
Most strokes are caused by occlusion of a major cerebral artery, and substantial advances …
Most strokes are caused by occlusion of a major cerebral artery, and substantial advances …
Insights gained from single-cell analysis of immune cells in the tumor microenvironment
Understanding tumor immune microenvironments is critical for identifying immune modifiers
of cancer progression and developing cancer immunotherapies. Recent applications of …
of cancer progression and developing cancer immunotherapies. Recent applications of …