Type 2 inflammation is characterized by overexpression and heightened activity of type 2
cytokines, mediators and cells that drive neuroimmune activation and sensitization to …

Barrier tissues are highly innervated by sensory and autonomic nerves that are positioned in
close proximity to both stromal and immune cell populations. Together with a growing …

Pulmonary neuroendocrine cells (PNECs) are rare airway cells with potential sensory
capacity linked to vagal neurons and immune cells. How PNECs sense and respond to …

Cytokines employ downstream Janus kinases (JAKs) to promote chronic inflammatory
diseases. JAK1-dependent type 2 cytokines drive allergic inflammation, and patients with …

Transient receptor potential ankyrin 1 (TRPA1) is a polymodal cation channel that is
activated by electrophilic irritants, oxidative stress, cold temperature, and GPCR signaling …

The airways are densely innervated by sensory afferent nerves, whose activation regulates
respiration and triggers defensive reflexes (eg, cough, bronchospasm). Airway innervation is …

Although increased neuropeptides are often detected in lungs that exhibit respiratory
distress, whether they contribute to the condition is unknown. Here, we show in a mouse …

Bone and dental tissues are richly innervated by sensory and sympathetic neurons.
However, the characterization of the morphology, molecular phenotype, and distribution of …

Coughing is a respiratory behavior that plays a crucial role in protecting the respiratory
system. Here we show that the nucleus of the solitary tract (NTS) in mice contains …

Asthma pathobiology includes oxidative stress that modifies cell membranes and
extracellular phospholipids. Oxidized phosphatidylcholines (OxPCs) in lung lavage from …