Sixteen years ago, the Nomenclature Committee of the International Union of Pharmacology
approved a system for naming human seven-transmembrane (7TM) G protein-coupled …

Chemokine receptors comprise a large family of seven transmembrane domain G protein-
coupled receptors differentially expressed in diverse cell types. Biological activities have …

Clinical acute lung injury (ALI) is a major cause of acute respiratory failure in critically ill
patients. There is considerable experimental and clinical evidence that pro-and anti …

Chemokines are small peptides that are potent activators and chemoattractants for leukocyte
subpopulations and some nonhemopoietic cells. Their actions are mediated by a family of 7 …

At sites of inflammation and in normal immune surveillance, chemokines direct leukocyte
migration across the endothelium. Many cell types that are extravascular can produce …

Leukocyte migration into tissues depends on the activity of chemokines that form
concentration gradients to guide leukocytes to a specific site. Interaction of chemokines with …

The Duffy antigen receptor for chemokines (DARC) belongs to a family of'silent'heptahelical
chemokine receptors that do not couple to G proteins and fail to transmit measurable …

Sixteen years ago, the Nomenclature Committee of the International Union of Pharmacology
approved a system for naming human seven-transmembrane (7TM) G protein-coupled …

Regulation of the availability of chemokine SDF-1 (CXCL12) in bone marrow is still not fully
understood. Here we describe a unique function for the chemokine receptor CXCR4 …

Background Intravascular leukocyte recruitment in most vertebrate tissues is restricted to
postcapillary and collecting venules, whereas capillaries and arterioles usually support little …