A consequence of our progressively ageing global population is the increasing prevalence
of worldwide age-related cognitive decline and dementia. In the absence of effective …

Microglial dystrophy has recently been described as a morphological phenotype of microglia
that differs from resting and activated states by spheroid formation and cytorrhexis. In thick …

As a major characteristic of aging process, neuroinflammation is involved in the
pathogenesis of several aging-related diseases including Alzheimer's disease (AD) …

The prevalence of depression is increasing, and geriatric depression, in particular, is difficult
to recognize and treat. Depression in older adults is often accompanied by …

Age is the main risk factor for sporadic Alzheimer's disease. Yet, cognitive decline in aged
rodents has been less well studied, possibly due to concomitant changes in sensory or …

The worldwide increase in cognitive decline, both in aging and with psychiatric disorders,
warrants a search for pharmacological treatment. Although dopaminergic treatment …

Abstract H1 histamine receptor (H1HR) belongs to the family of rhodopsin-like G-protein-
coupled receptors. Recent studies have shown that H1HR expression is increased in …

Neuroinflammation is recognized as an important pathogenic factor for aging and related
cognitive disorders. Mitogen-activated protein kinase and nuclear factor kappa B signaling …

Similar to humans, the normal aged rat population is not homogeneous in terms of cognitive
function. Two distinct subpopulations of aged Sprague–Dawley rats can be identified on the …

In humans, memory capacities are generally affected with aging, even without any reported
neurologic disorders. The mechanisms behind cognitive decline are not well understood …