Comprehensive metabonomic analysis of heart tissue from isoproterenol‐induced myocardial infarction rat based on reversed‐phase and hydrophilic interaction …

L Sun, J Liu, M Sun, L Lin, L Miao… - Journal of separation …, 2017 - Wiley Online Library
We aim to describe the metabonomic characteristics of myocardial infarction rats. High‐
performance liquid chromatography coupled with quadrupole time‐of‐flight mass …

[HTML][HTML] Do wearing masks and preservatives have a combined effect on skin health?

Y Liu, L Chen, S Zhang, X Wang, Y Song, H Sun… - Eco-Environment & …, 2024 - Elsevier
Chemical exposure and local hypoxia caused by mask-wearing may result in skin
physiology changes. The effects of methylparaben (MeP), a commonly used preservative in …

Normalizing dysfunctional purine metabolism accelerates diabetic wound healing

AL Weinstein, FD Lalezarzadeh… - Wound Repair and …, 2015 - Wiley Online Library
Diabetic patients exhibit dysfunction of the normal wound healing process, leading to local
ischemia by vascular occlusive disease as well as sustained increases in the …

Species-specific involvement of aldehyde oxidase and xanthine oxidase in the metabolism of the pyrimidine-containing mGlu5-negative allosteric modulator …

RD Crouch, AL Blobaum, AS Felts, PJ Conn… - Drug Metabolism and …, 2017 - ASPET
Aldehyde oxidase (AO) and xanthine oxidase (XO) are molybdo-flavoenzymes that catalyze
oxidation of aromatic azaheterocycles. Differences in AO activity have been reported among …

Plasma xanthine oxidoreductase activity in patients with decompensated acute heart failure requiring intensive care

H Okazaki, A Shirakabe, M Matsushita… - ESC heart …, 2019 - Wiley Online Library
Aims Plasma xanthine oxidoreductase (XOR) activity during the acute phase of acute heart
failure (AHF) requires further elucidation. Methods and results One hundred eighteen AHF …

Cellular mechanisms against ischemia reperfusion injury induced by the use of anesthetic pharmacological agents

P Alvarez, L Tapia, LA Mardones… - Chemico-Biological …, 2014 - Elsevier
Ischemia–reperfusion (IR) cycle in the myocardium is associated with activation of an
injurious cascade, thus leading to new myocardial challenges, which account for up to 50 …

[HTML][HTML] Hyperuricemia complicated with acute kidney injury is associated with adverse outcomes in patients with severely decompensated acute heart failure

A Shirakabe, H Okazaki, M Matsushita, Y Shibata… - IJC Heart & …, 2019 - Elsevier
Background The relationship between the serum level of uric acid (UA) and the acute kidney
injury on admission in patients with acute heart failure (AHF) remain unclear. Methods and …

[HTML][HTML] Impact of urate level on cardiovascular risk in allopurinol treated patients. A nested case-control study

K Søltoft Larsen, A Pottegård, HM Lindegaard… - PLoS One, 2016 - journals.plos.org
Background Gout gives rise to increased risk of cardiovascular events. Gout attacks can be
effectively prevented with urate lowering drugs, and allopurinol potentially reduces …

New 1, 4‐dihydropyridines down‐regulate nitric oxide in animals with streptozotocin‐induced diabetes mellitus and protect deoxyribonucleic acid against peroxynitrite …

E Leonova, J Sokolovska, JL Boucher… - Basic & clinical …, 2016 - Wiley Online Library
Diabetes mellitus (DM) and its complications cause numerous health and social problems
throughout the world. Pathogenic actions of nitric oxide (NO) are responsible to a large …

Evaluation of the Antihyperuricemic Activity of Phytochemicals from Davallia formosana by Enzyme Assay and Hyperuricemic Mice Model

CY Chen, CC Huang, KC Tsai… - Evidence‐Based …, 2014 - Wiley Online Library
Abnormal serum urate levels are recognized as a critical factor in the progression of several
chronic diseases. To evaluate the antihyperuricemic effect of Davallia formosana, the …