Pathophysiological mechanisms of reduced physical activity: Insights from the human step reduction model and animal analogues

F Sarto, R Bottinelli, MV Franchi, S Porcelli… - Acta …, 2023 - Wiley Online Library
Physical inactivity represents a heavy burden for modern societies and is spreading
worldwide, it is a recognised pandemic and is the fourth cause of global mortality. Not …

Autonomic dysfunction in post-COVID patients with and witfhout neurological symptoms: a prospective multidomain observational study

A Buoite Stella, G Furlanis, NA Frezza, R Valentinotti… - Journal of …, 2022 - Springer
The autonomic nervous system (ANS) can be affected by COVID-19, and dysautonomia may
be a possible complication in post-COVID individuals. Orthostatic hypotension (OH) and …

[HTML][HTML] The burden of space exploration on the mental health of astronauts: a narrative review

A Arone, T Ivaldi, K Loganovsky, S Palermo… - Clinical …, 2021 - ncbi.nlm.nih.gov
Abstract Space travel, a topic of global interest, has always been a fascinating matter, as its
potential appears to be infinite. The development of advanced technologies has made it …

[HTML][HTML] Impact of different ground-based microgravity models on human sensorimotor system

A Saveko, M Bekreneva, I Ponomarev… - Frontiers in …, 2023 - frontiersin.org
This review includes current and updated information about various ground-based
microgravity models and their impact on the human sensorimotor system. All known models …

Homo sapiens—A Species Not Designed for Space Flight: Health Risks in Low Earth Orbit and Beyond, Including Potential Risks When Traveling beyond the …

DA Hart - Life, 2023 - mdpi.com
Homo sapiens and their predecessors evolved in the context of the boundary conditions of
Earth, including a 1 g gravity and a geomagnetic field (GMF). These variables, plus others …

Intravenous immunoglobulin response in new-onset refractory status epilepticus (NORSE) COVID-19 adult patients

P Manganotti, G Furlanis, M Ajčević, C Moras… - Journal of …, 2021 - Springer
Neurological manifestations may be common in COVID-19 patients. They may include
several syndromes, such as a suggested autoimmune abnormal response, which may result …

Are skeletal muscle changes during prolonged space flights similar to those experienced by frail and sarcopenic older adults?

A Cannavo, A Carandina, G Corbi, E Tobaldini… - Life, 2022 - mdpi.com
Microgravity exposure causes several physiological and psychosocial alterations that
challenge astronauts' health during space flight. Notably, many of these changes are mostly …

Cerebrospinal fluid and serum interleukins 6 and 8 during the acute and recovery phase in COVID‐19 neuropathy patients

P Manganotti, G Bellavita, V Tommasini… - Journal of Medical …, 2021 - Wiley Online Library
This case series describes three patients affected by severe acute respiratory syndrome
coronavirus 2, who developed polyradiculoneuritis as a probable neurological complication …

Peripheral nerve adaptations to 10 days of horizontal bed rest in healthy young adult males

P Manganotti, A Buoite Stella… - American Journal …, 2021 - journals.physiology.org
Space analogs, such as bed rest, are used to reproduce microgravity-induced
morphological and physiological changes and can be used as clinical models of prolonged …

The unresolved methodological challenge of detecting neuroplastic changes in astronauts

F Burles, R Williams, L Berger, GB Pike, C Lebel… - Life, 2023 - mdpi.com
After completing a spaceflight, astronauts display a salient upward shift in the position of the
brain within the skull, accompanied by a redistribution of cerebrospinal fluid. Magnetic …