Molecular determinants of immunogenic cell death elicited by radiation therapy

C Galassi, V Klapp, T Yamazaki… - Immunological …, 2024 - Wiley Online Library
Cancer cells undergoing immunogenic cell death (ICD) can initiate adaptive immune
responses against dead cell‐associated antigens, provided that (1) said antigens are not …

SOHO state of the art updates and next questions: novel therapies in development for myelofibrosis

HT Chifotides, P Bose, L Masarova… - … Myeloma and Leukemia, 2022 - Elsevier
Myeloproliferative neoplasms research has entered a dynamic and exciting era as we
witness exponential growth of novel agents in advanced/early phase clinical trials for …

Production and characterization of peptide antibodies to the C-terminal of frameshifted calreticulin associated with myeloproliferative diseases

FP Mughal, AC Bergmann, HUB Huynh… - International Journal of …, 2022 - mdpi.com
Myeloproliferative Neoplasms (MPNs) constitute a group of rare blood cancers that are
characterized by mutations in bone marrow stem cells leading to the overproduction of …

Structural and dynamic differences between calreticulin mutants associated with essential thrombocythemia

R Radjasandirane, AG de Brevern - Biomolecules, 2023 - mdpi.com
Essential thrombocythemia (ET) is a blood cancer. ET is characterized by an overproduction
of platelets that can lead to thrombosis formation. Platelet overproduction occurs in …

[HTML][HTML] Antibodies to calnexin and mutated calreticulin are common in human sera

C Kyllesbech, N Trier, F Mughal, P Hansen… - Current research in …, 2023 - Elsevier
Purpose of the study Calreticulin is an endoplasmic reticulum chaperone protein, which is
involved in protein folding and in peptide loading of major histocompatibility complex class I …

JAK2V617F drives gut microbiota differences in patients with myeloproliferative neoplasms

CS Eickhardt‐Dalbøge, HV Nielsen… - European Journal of …, 2024 - Wiley Online Library
Background Essential thrombocythemia (ET), polycythemia vera (PV), and primary
myelofibrosis (MF) are myeloproliferative neoplasms (MPN). Inflammation is involved in the …

RT-PCR-assisted quantification of type I IFN responses in irradiated cancer cells

C Galassi, Y Ruan, A Sato, C Jiménez-Cortegana… - Methods in Cell …, 2022 - Elsevier
It is now clear that radiation therapy (RT) can be delivered in doses and according to
fractionation schedules that actively elicit immunostimulatory effects. While such effects are …