Tumor microenvironment as a therapeutic target in cancer

Y Xiao, D Yu - Pharmacology & therapeutics, 2021 - Elsevier
Tumor microenvironment denotes the non-cancerous cells and components presented in
the tumor, including molecules produced and released by them. The constant interactions …

Toward multi-targeted platinum and ruthenium drugs—a new paradigm in cancer drug treatment regimens?

RG Kenny, CJ Marmion - Chemical reviews, 2019 - ACS Publications
While medicinal inorganic chemistry has been practised for over 5000 years, it was not until
the late 1800s when Alfred Werner published his ground-breaking research on coordination …

PPAR-γ signaling in nonalcoholic fatty liver disease: Pathogenesis and therapeutic targets

H Chen, H Tan, J Wan, Y Zeng, J Wang… - Pharmacology & …, 2023 - Elsevier
Non-alcoholic fatty liver disease (NAFLD), currently the leading cause of global chronic liver
disease, has emerged as a major public health problem, more efficient therapeutics of which …

Targeting inflammation in cancer prevention and therapy

J Todoric, L Antonucci, M Karin - Cancer Prevention Research, 2016 - AACR
Inflammation is associated with the development and malignant progression of most
cancers. As most of the cell types involved in cancer-associated inflammation are genetically …

A critical review on recent trends on pharmacological applications of pyrazolone endowed derivatives

G Mustafa, M Zia-ur-Rehman, SH Sumrra… - Journal of Molecular …, 2022 - Elsevier
Pyrazolone is a well-known influential synthon for the synthesis of many molecules which
hold remarkable potential in the advancement of functional materials, coordination …

[HTML][HTML] Red meat and colorectal cancer

NF Aykan - Oncology reviews, 2015 - ncbi.nlm.nih.gov
Colorectal cancer (CRC) is the third most common cancer in men and the second in women
worldwide. More than half of cases occur in more developed countries. The consumption of …

[HTML][HTML] Anticancer activity of oleanolic acid and its derivatives: Recent advances in evidence, target profiling and mechanisms of action

ZY Tang, Y Li, YT Tang, XD Ma, ZY Tang - Biomedicine & Pharmacotherapy, 2022 - Elsevier
Abstract Oleanolic acid (OA, 3 β-hydroxyoleanolic acid-12-en-28-oic acid) is a pentacyclic
triterpenoid present in many plants. As a new framework for development of semi synthetic …

Design concepts of half-sandwich organoruthenium anticancer agents based on bidentate bioactive ligands

WDJ Tremlett, DM Goodman, TR Steel, S Kumar… - Coordination chemistry …, 2021 - Elsevier
The small molecule anticancer agent cisplatin and its Pt (II) analogs carboplatin and
oxaliplatin are widely used to treat a variety of tumorigenic diseases. Despite their structural …

[PDF][PDF] Prostaglandin pathways: opportunities for cancer prevention and therapy

Q Wang, RJ Morris, AM Bode, T Zhang - Cancer research, 2022 - AACR
Because of profound effects observed in carcinogenesis, prostaglandins (PGs),
prostaglandin-endoperoxide synthases, and PG receptors are implicated in cancer …

Mechanism of apoptosis induced by curcumin in colorectal cancer

NI Ismail, I Othman, F Abas, N H. Lajis… - International journal of …, 2019 - mdpi.com
Colorectal cancer (CRC) is among the top three cancer with higher incident and mortality
rate worldwide. It is estimated that about over than 1.1 million of death and 2.2 million new …