Chronic infection with hepatitis C virus (HCV) can induce insulin resistance (IR) in a
genotype‐dependent fashion, thus contributing to steatosis, progression of fibrosis and …

Hepatocellular carcinoma (HCC) is a major health problem worldwide responsible for 500
000 deaths annually. A number of risk factors are associated with either the induction of the …

N 6-Methyladenosine (m 6 A), the methylation of the adenosine base at the nitrogen 6
position, is the most common epitranscriptomic modification of mRNA that affects a wide …

Worldwide, hepatocellular carcinoma (HCC) is one of the most common cancers. It is
thought that 80% of hepatocellular carcinomas are linked to chronic infections with the …

Posttranscriptional regulation of gene expression is now recognized as an important
contributor to disease pathogenesis, whose mechanisms include alterations in the function …

Invasion by infectious pathogens can elicit a range of cytokine responses from host cells.
These cytokines provide the initial host defense mechanism. In this report, we demonstrate …

Abstract TRIM22, a tripartite-motif (TRIM) protein, is upregulated upon interferon alpha
(IFNα) administration to hepatitis C virus (HCV)-infected patients. However, the physiological …

Cyclophilin A (CypA), a key member of the immunophilin family, is the most abundantly
expressed isozyme of the 18 known human cyclophilins. Besides acting as an intracellular …

As an RNA virus, hepatitis C virus (HCV) shows a characteristically high level of nucleotide
diversity. Accumulation of nucleotide substitutions in the virus has resulted in diversification …

Chronic inflammation as a result of viral infection significantly increases the likelihood of
cancer development. A handful of diverse viruses have confirmed roles in cancer …