[HTML][HTML] Molecular mechanisms and clinical application of multipotent stem cells for spinal cord injury

M Szymoniuk, J Litak, L Sakwa, A Dryla, W Zezuliński… - Cells, 2022 - mdpi.com
Spinal Cord Injury (SCI) is a common neurological disorder with devastating psychical and
psychosocial sequelae. The majority of patients after SCI suffer from permanent disability …

[HTML][HTML] Vimentin as a potential target for diverse nervous system diseases

KZ Chen, SX Liu, YW Li, T He, J Zhao… - Neural regeneration …, 2023 - journals.lww.com
Vimentin is a major type III intermediate filament protein that plays important roles in several
basic cellular functions including cell migration, proliferation, and division. Although vimentin …

[HTML][HTML] Spatiotemporal dynamics of the molecular expression pattern and intercellular interactions in the glial scar response to spinal cord injury

L Gong, Y Gu, X Han, C Luan, C Liu, X Wang… - Neuroscience …, 2023 - Springer
Nerve regeneration in adult mammalian spinal cord is poor because of the lack of intrinsic
regeneration of neurons and extrinsic factors–the glial scar is triggered by injury and inhibits …

[HTML][HTML] Astroglial Cells: Emerging Therapeutic Targets in the Management of Traumatic Brain Injury

W Czyżewski, M Mazurek, L Sakwa, M Szymoniuk… - Cells, 2024 - mdpi.com
Traumatic Brain Injury (TBI) represents a significant health concern, necessitating advanced
therapeutic interventions. This detailed review explores the critical roles of astrocytes, key …

Role of inflammation in neurological damage and regeneration following spinal cord injury and its therapeutic implications

Y Jin, Y Song, J Lin, T Liu, G Li, B Lai, Y Gu… - Burns & …, 2023 - academic.oup.com
Spinal cord injury (SCI) is an incurable trauma that frequently results in partial or complete
loss of motor and sensory function. Massive neurons are damaged after the initial …

[HTML][HTML] A tannic acid doped hydrogel with small extracellular vesicles derived from mesenchymal stem cells promotes spinal cord repair by regulating reactive oxygen …

Z Liu, S Guo, L Dong, P Wu, K Li, X Li, X Li, H Qian… - Materials Today Bio, 2022 - Elsevier
Spinal cord injury (SCI) is a serious disease of the central nervous system that is associated
with a poor prognosis; furthermore, existing clinical treatments cannot restore nerve function …

Role of CD36 in central nervous system diseases

M Feng, Q Zhou, H Xie, C Liu, M Zheng… - Neural Regeneration …, 2023 - journals.lww.com
CD36 is a highly glycosylated integral membrane protein that belongs to the scavenger
receptor class B family and regulates the pathological progress of metabolic diseases. CD36 …

Gas5 inhibition promotes the axon regeneration in the adult mammalian nervous system

X Han, J Xu, Z Chen, P Li, L Zhao, J Tao, Y Shen… - Experimental …, 2022 - Elsevier
Neurons in the peripheral nervous system (PNS) have robust regenerative capacity after
axon injury, but the regenerative capacity is generally absent in the neurons of the central …

[HTML][HTML] Shinbaro2 enhances axonal extension beyond the glial scar for functional recovery in rats with contusive spinal cord injury

JY Hong, J Lee, H Kim, C Yeo, WJ Jeon, YJ Lee… - Biomedicine & …, 2023 - Elsevier
Spinal cord injury (SCI) is a devastating event that often results in the inflammatory condition
of glial scar tissue formation, impeding neural regeneration and recovery. Reducing the …

MiR-135a-5p/SP1 Axis regulates spinal astrocyte proliferation and Migration

X Lin, Y Yang, Y Ji, G Wang, W Xu, B Wang, H Guo… - Neuroscience, 2023 - Elsevier
Following spinal cord injury (SCI), astrocyte activation and proliferation result in the
development of glial scars, which impede axonal growth and neurological recovery …