Aneuploidy and complex genomic rearrangements in cancer evolution

TM Baker, S Waise, M Tarabichi, P Van Loo - Nature cancer, 2024 - nature.com
Mutational processes that alter large genomic regions occur frequently in developing
tumors. They range from simple copy number gains and losses to the shattering and …

Mechanisms underlying spindle assembly and robustness

VA Valdez, L Neahring, S Petry… - Nature Reviews Molecular …, 2023 - nature.com
The microtubule-based spindle orchestrates chromosome segregation during cell division.
Following more than a century of study, many components and pathways contributing to …

A kinesin‐based approach for inducing chromosome‐specific mis‐segregation in human cells

MA Truong, P Cané‐Gasull, SG de Vries… - The EMBO …, 2023 - embopress.org
Various cancer types exhibit characteristic and recurrent aneuploidy patterns. The origins of
these cancer type‐specific karyotypes are still unknown, partly because introducing or …

Double-checking chromosome segregation

H Maiato, S Silva - Journal of Cell Biology, 2023 - rupress.org
Enduring chromosome segregation errors represent potential threats to genomic stability
due to eventual chromosome copy number alterations (aneuploidy) and formation of …

[HTML][HTML] An anaphase surveillance mechanism prevents micronuclei formation from frequent chromosome segregation errors

B Orr, F De Sousa, AM Gomes, O Afonso, LT Ferreira… - Cell Reports, 2021 - cell.com
Micronuclei are a hallmark of cancer and several other human disorders. Recently,
micronuclei were implicated in chromothripsis, a series of massive genomic rearrangements …

Smart lattice light-sheet microscopy for imaging rare and complex cellular events

Y Shi, JS Tabet, DE Milkie, TA Daugird, CQ Yang… - Nature …, 2024 - nature.com
Light-sheet microscopes enable rapid high-resolution imaging of biological specimens;
however, biological processes span spatiotemporal scales. Moreover, long-term phenotypes …

Measuring and modeling the dynamics of mitotic error correction

G Ha, P Dieterle, H Shen, A Amir… - Proceedings of the …, 2024 - National Acad Sciences
Error correction is central to many biological systems and is critical for protein function and
cell health. During mitosis, error correction is required for the faithful inheritance of genetic …

[HTML][HTML] The second half of mitosis and its implications in cancer biology

D Moreno-Andrés, K Holl, W Antonin - Seminars in Cancer Biology, 2023 - Elsevier
The nucleus undergoes dramatic structural and functional changes during cell division. With
the entry into mitosis, in human cells the nuclear envelope breaks down, chromosomes …

[HTML][HTML] Aurora kinases: Generators of spatial control during mitosis

A Ali, PT Stukenberg - Frontiers in Cell and Developmental Biology, 2023 - frontiersin.org
Cell division events require regulatory systems to ensure that events happen in a distinct
order. The classic view of temporal control of the cell cycle posits that cells order events by …

Twenty years of merotelic kinetochore attachments: a historical perspective

D Cimini - Chromosome Research, 2023 - Springer
Micronuclei, small DNA-containing structures separate from the main nucleus, were used for
decades as an indicator of genotoxic damage. Micronuclei containing whole chromosomes …