The microtubule-based spindle orchestrates chromosome segregation during cell division.
Following more than a century of study, many components and pathways contributing to …

Enduring chromosome segregation errors represent potential threats to genomic stability
due to eventual chromosome copy number alterations (aneuploidy) and formation of …

Various cancer types exhibit characteristic and recurrent aneuploidy patterns. The origins of
these cancer type‐specific karyotypes are still unknown, partly because introducing or …

Light-sheet microscopes enable rapid high-resolution imaging of biological specimens;
however, biological processes span spatiotemporal scales. Moreover, long-term phenotypes …

Micronuclei are a hallmark of cancer and several other human disorders. Recently,
micronuclei were implicated in chromothripsis, a series of massive genomic rearrangements …

Cell division events require regulatory systems to ensure that events happen in a distinct
order. The classic view of temporal control of the cell cycle posits that cells order events by …

Mutational processes that alter large genomic regions occur frequently in developing
tumors. They range from simple copy number gains and losses to the shattering and …

The nucleus undergoes dramatic structural and functional changes during cell division. With
the entry into mitosis, in human cells the nuclear envelope breaks down, chromosomes …

The process of chromosome congression and alignment is at the core of mitotic fidelity. In
this review, we discuss distinct spatial routes that the chromosomes take to align during …

DNA damage response (DDR) during interphase involves active signaling and repair to
ensure genomic stability. However, how mitotic cells respond to DNA damage remains …