All roads lead to directional cell migration

A Shellard, R Mayor - Trends in cell biology, 2020 - cell.com
Directional cell migration normally relies on a variety of external signals, such as chemical,
mechanical, or electrical, which instruct cells in which direction to move. Many of the major …

Microtubule targeting agents in disease: classic drugs, novel roles

L Wordeman, JJ Vicente - Cancers, 2021 - mdpi.com
Simple Summary Microtubules (MTs) are highly conserved proteins present in all eukaryotic
organisms. They form the cell cytoskeleton, and its function is essential for a large number of …

Unravelling cell migration: defining movement from the cell surface

F Merino-Casallo, MJ Gomez-Benito… - Cell adhesion & …, 2022 - Taylor & Francis
Cell motility is essential for life and development. Unfortunately, cell migration is also linked
to several pathological processes, such as cancer metastasis. Cells' ability to migrate relies …

Public RNA-seq data-based identification and functional analyses reveal that MXRA5 retains proliferative and migratory abilities of dental pulp stem cells

K Yoshida, S Suzuki, H Yuan, A Sato… - Scientific Reports, 2023 - nature.com
Dental pulp stem cells (DPSC) usually remain quiescent in the dental pulp tissue; however,
once the dental pulp tissue is injured, DPSCs potently proliferate and migrate into the injury …

Syndecan-4 in tumor cell motility

A Keller-Pinter, S Gyulai-Nagy, D Becsky, L Dux… - Cancers, 2021 - mdpi.com
Simple Summary Cell migration is crucial fReaor metastasis formation and a hallmark of
malignancy. The primary cause of high mortality among oncology patients is the ability of …

Binding blockade between TLN1 and integrin β1 represses triple-negative breast cancer

Y Zhang, L Sun, H Li, L Ai, Q Ma, X Qiao, J Yang… - Elife, 2022 - elifesciences.org
Background: Integrin family are known as key gears in focal adhesion for triple-negative
breast cancer (TNBC) metastasis. However, the integrin independent factor TLN1 remains …

Role of intermediate filaments in blood–brain barrier in health and disease

E Bayir, A Sendemir - Cells, 2021 - mdpi.com
The blood–brain barrier (BBB) is a highly selective cellular monolayer unique to the
microvasculature of the central nervous system (CNS), and it mediates the communication of …

Mitotic centromere-associated kinesin (MCAK/KIF2C) regulates cell migration and invasion by modulating microtubule dynamics and focal adhesion turnover

HH Moon, NN Kreis, A Friemel, S Roth, D Schulte… - Cancers, 2021 - mdpi.com
Simple Summary The microtubule (MT) cytoskeleton is a crucial factor for organized cell
motility and migration of cancer as well as benign cells. Mitotic centromere-associated …

Magic-angle-spinning NMR structure of the kinesin-1 motor domain assembled with microtubules reveals the elusive neck linker orientation

C Zhang, C Guo, RW Russell, CM Quinn, M Li… - Nature …, 2022 - nature.com
Microtubules (MTs) and their associated proteins play essential roles in maintaining cell
structure, organelle transport, cell motility, and cell division. Two motors, kinesin and …

Intrinsic mechanisms regulating neuronal migration in the postnatal brain

C Bressan, A Saghatelyan - Frontiers in Cellular Neuroscience, 2021 - frontiersin.org
Neuronal migration is a fundamental brain development process that allows cells to move
from their birthplaces to their sites of integration. Although neuronal migration largely ceases …