Salvia miltiorrhizaBurge (Danshen): a golden herbal medicine in cardiovascular therapeutics

Z Li, S Xu, P Liu - Acta Pharmacologica Sinica, 2018 - nature.com
Abstract Salvia miltiorrhiza Burge (Danshen) is an eminent medicinal herb that possesses
broad cardiovascular and cerebrovascular protective actions and has been used in Asian …

Endothelial shear stress signal transduction and atherogenesis: from mechanisms to therapeutics

L He, CL Zhang, Q Chen, L Wang, Y Huang - Pharmacology & therapeutics, 2022 - Elsevier
Atherosclerotic vascular disease and its complications are among the top causes of mortality
worldwide. In the vascular lumen, atherosclerotic plaques are not randomly distributed …

Targeting mechanosensitive transcription factors in atherosclerosis

N Niu, S Xu, Y Xu, PJ Little, ZG Jin - Trends in pharmacological sciences, 2019 - cell.com
Atherosclerosis is the primary underlying cause of cardiovascular disease which
preferentially develops at arterial regions exposed to disturbed flow (DF), but much less at …

Therapeutic potential of polyphenols in cardiovascular diseases: Regulation of mTOR signaling pathway

A Sanches-Silva, L Testai, SF Nabavi, M Battino… - Pharmacological …, 2020 - Elsevier
Cardiovascular diseases comprise of non-communicable disorders that involve the heart
and/or blood vessels and have become the leading cause of death worldwide with …

Targeting foam cell formation in atherosclerosis: therapeutic potential of natural products

D Wang, Y Yang, Y Lei, NT Tzvetkov, X Liu… - Pharmacological …, 2019 - ASPET
Foam cell formation and further accumulation in the subendothelial space of the vascular
wall is a hallmark of atherosclerotic lesions. Targeting foam cell formation in the …

Icariin, an anti-atherosclerotic drug from Chinese medicinal herb horny goat weed

J Fang, Y Zhang - Frontiers in pharmacology, 2017 - frontiersin.org
Icariin is a major bioactive pharmaceutical constituent isolated from Chinese medicine
Horny Goat Weed (Ying Yang Huo) with potent cardiovascular protective functions …

[HTML][HTML] Flow-dependent epigenetic regulation of IGFBP5 expression by H3K27me3 contributes to endothelial anti-inflammatory effects

S Xu, Y Xu, M Yin, S Zhang, P Liu, M Koroleva, S Si… - Theranostics, 2018 - ncbi.nlm.nih.gov
Rationale: Atherosclerosis is a chronic inflammatory and epigenetic disease that is
influenced by different patterns of blood flow. However, the epigenetic mechanism whereby …

[HTML][HTML] Systematic analysis of tRNA-derived small RNAs reveals novel potential therapeutic targets of traditional Chinese medicine (Buyang-Huanwu-Decoction) on …

P Li, T Tang, T Liu, J Zhou, H Cui, Z He… - … Journal of Biological …, 2019 - ncbi.nlm.nih.gov
Abstract Although Buyang-Huanwu-Decoction (BYHWD), a famous traditional Chinese
medicine, has been utilized to promote the recovery of neurological function in intracerebral …

Phosphatidylserine-specific phospholipase A1: A friend or the devil in disguise

Y Zhao, S Hasse, SG Bourgoin - Progress in Lipid Research, 2021 - Elsevier
Various human tissues and cells express phospholipase A1 member A (PLA1A), including
the liver, lung, prostate gland, and immune cells. The enzyme belongs to the pancreatic …

A simple protocol for isolating mouse lung endothelial cells

J Wang, N Niu, S Xu, ZG Jin - Scientific reports, 2019 - nature.com
Endothelial dysfunction is the common molecular basis of multiple human diseases, such as
atherosclerosis, diabetes, hypertension, and acute lung injury. Therefore, primary isolation …