[HTML][HTML] Intravenous levothyroxine for unstable brain-dead heart donors

R Dhar, GF Marklin, WD Klinkenberg… - … England Journal of …, 2023 - Mass Medical Soc
Background Hemodynamic instability and myocardial dysfunction are major factors
preventing the transplantation of hearts from organ donors after brain death. Intravenous …

Efficacy and safety of triiodothyronine treatment in cardiac surgery or cardiovascular diseases: A systematic review and meta-analysis of randomized controlled trials

M Tharmapoopathy, A Thavarajah, RPW Kenny… - Thyroid, 2022 - liebertpub.com
Background: Low levels of the active thyroid hormone triiodothyronine (T3) in cardiac
patients are associated with worse outcomes. The aim of this analysis was to assess if T3 …

Novel uses of thyroid hormones in cardiovascular conditions

S Razvi - Endocrine, 2019 - Springer
Thyroid hormone levels are reduced in cardiovascular diseases and this phenomenon is
associated with worse outcomes. It is unclear whether the changes in thyroid hormone …

Donor heart selection: Evidence-based guidelines for providers

H Copeland, I Knezevic, DA Baran, V Rao… - The Journal of Heart and …, 2023 - Elsevier
The proposed donor heart selection guidelines provide evidence-based and expert-
consensus recommendations for the selection of donor hearts following brain death. These …

Management of the neurologically deceased organ donor: a Canadian clinical practice guideline

IM Ball, L Hornby, B Rochwerg, MJ Weiss, C Gillrie… - Cmaj, 2020 - Can Med Assoc
This clinical practice guideline is intended for use in the care of both neurologically
deceased adult and pediatric potential organ donors. We based our recommendations on …

Donor thyroid hormone therapy and heart transplantation outcomes: ISHLT transplant registry analysis

Y Peled, E Ram, R Klempfner, J Lavee… - The Journal of Heart and …, 2020 - Elsevier
BACKGROUND Donor thyroid hormone (TH) supplementation therapy is widely used.
Recent reports suggested an increased risk of graft dysfunction in heart transplant (HTx) …

A randomized trial comparing triiodothyronine (T3) with thyroxine (T4) for hemodynamically unstable brain‐dead organ donors

R Dhar, E Stahlschmidt, Y Yan… - Clinical …, 2019 - Wiley Online Library
Rationale Brain‐dead (BD) organ donors frequently exhibit hemodynamic instability and/or
reversible cardiac dysfunction. Retrospective studies have suggested that thyroid hormone …

A randomized trial of intravenous thyroxine for brain-dead organ donors with impaired cardiac function

R Dhar, E Stahlschmidt… - Progress in …, 2020 - journals.sagepub.com
Rationale: Brain death (BD) precipitates cardiac dysfunction impairing the ability to
transplant hearts from eligible organ donors. Retrospective studies have suggested that …

Donor thyroid hormone therapy is associated with an increased risk of graft dysfunction after heart transplantation

Y Peled, J Lavee, Y Kassif, M Arad… - Clinical …, 2020 - Wiley Online Library
Objective Heart transplantation (HT) is uniquely associated with the potential impact of
thyroid hormone therapy at three intersecting levels—donor, operation, and recipient. We …

Thyroid hormone resuscitation after brain death in potential organ donors: a primer for neurocritical care providers and narrative review of the literature

IA Buchanan, VA Mehta - Clinical Neurology and Neurosurgery, 2018 - Elsevier
Solid organ transplantation has become a mainstay in the contemporary management of
end-stage organ failures fueled by advances in immunosuppression, intensive care and …