Ischemic heart disease (IHD) is the leading cause of disability and mortality worldwide.
Reactive oxygen species (ROS) have been shown to play key roles in the progression of …

Oxidative stress and chronic inflammation are known to be associated with the development
of metabolic diseases, including diabetes. Oxidative stress, an imbalance between oxidative …

Psychosocial maternal stress experienced during different vulnerable periods throughout
gestation is thought to increase the individual's risk to develop neuropsychiatric …

Arachidonic acid can be oxygenated by a variety of different enzymes, including
lipoxygenases, cyclooxygenases, and cytochrome P450s, and can be converted to a …

Although the currently available antidiabetic medications are effective in managing
hyperglycemia, vascular complications are common in diabetic patients. Cohort studies …

Among the family of phospholipases A 2 (PLA 2 s) are the Ca 2+-independent PLA 2 s (iPLA
2 s) and they are designated group VI iPLA 2 s. In relation to secretory and cytosolic PLA 2 s …

ALOX12 encodes arachidonic acid 12-lipoxygenase that acts on different polyunsaturated
fatty acid substrates to produce biologically active lipid mediators including eicosanes and …

Lipoxygenases (LOXs) are lipid metabolizing enzymes that catalyze the di-oxygenation of
polyunsaturated fatty acids to generate active eicosanoid products. 12-lipoxygenases (12 …

Aims/hypothesis Chronic inflammation in type 2 diabetes is proposed to affect islets as well
as insulin target organs. However, the nature of islet inflammation and its effects on islet …

Arteriosclerosis causes significant morbidity and mortality worldwide. Central to this process
is the development of subclinical non-atherosclerotic intimal lesions before the appearance …