Abstract Calcium (Ca 2+) is a ubiquitous second messenger that regulates various activities
in eukaryotic cells. Especially important role calcium plays in excitable cells. Neurons …

The presenilins are the catalytic subunit of the membrane-embedded tetrameric γ-secretase
protease complexes. More that 90 transmembrane proteins have been reported to be γ …

Background Postoperative cognitive dysfunction (POCD) is a very common complication that
might increase the morbidity and mortality of elderly patients after surgery. However, the …

Alzheimer9s disease (AD) is the most common reason for elderly dementia in the world. We
proposed that memory loss in AD is related to destabilization of mushroom postsynaptic …

Only two genome-wide significant loci associated with longevity have been identified so far,
probably because of insufficient sample sizes of centenarians, whose genomes may harbor …

The mechanisms underlying ryanodine receptor (RyR) dysfunction associated with
Alzheimer disease (AD) are still not well understood. Here, we show that neuronal RyR2 …

Mushroom dendritic spine structures are essential for memory storage and the loss of
mushroom spines may explain memory defects in aging and Alzheimer9s disease (AD). The …

Postoperative cognitive dysfunction (POCD) is a disturbing neurological complication in
patients undergoing anesthesia and surgical procedures. Brain-derived neurotrophic factor …

Accumulating evidence suggests that modulating the sigma 2 receptor (Sig2R) can provide
beneficial effects for neurodegenerative diseases. Herein, we report the identification of a …

In both excitable and non-excitable cells, calcium (Ca2+) signals are maintained by a highly
integrated process involving store-operated Ca2+ entry (SOCE), namely the opening of …