Calcium signaling and molecular mechanisms underlying neurodegenerative diseases
Abstract Calcium (Ca 2+) is a ubiquitous second messenger that regulates various activities
in eukaryotic cells. Especially important role calcium plays in excitable cells. Neurons …
in eukaryotic cells. Especially important role calcium plays in excitable cells. Neurons …
Beyond γ-secretase activity: The multifunctional nature of presenilins in cell signalling pathways
SP Duggan, JV McCarthy - Cellular signalling, 2016 - Elsevier
The presenilins are the catalytic subunit of the membrane-embedded tetrameric γ-secretase
protease complexes. More that 90 transmembrane proteins have been reported to be γ …
protease complexes. More that 90 transmembrane proteins have been reported to be γ …
Sirtuin 3 protects against anesthesia/surgery-induced cognitive decline in aged mice by suppressing hippocampal neuroinflammation
Q Liu, YM Sun, H Huang, C Chen, J Wan… - Journal of …, 2021 - Springer
Background Postoperative cognitive dysfunction (POCD) is a very common complication that
might increase the morbidity and mortality of elderly patients after surgery. However, the …
might increase the morbidity and mortality of elderly patients after surgery. However, the …
Neuronal store-operated calcium entry and mushroom spine loss in amyloid precursor protein knock-in mouse model of Alzheimer's disease
H Zhang, L Wu, E Pchitskaya, O Zakharova… - Journal of …, 2015 - Soc Neuroscience
Alzheimer9s disease (AD) is the most common reason for elderly dementia in the world. We
proposed that memory loss in AD is related to destabilization of mushroom postsynaptic …
proposed that memory loss in AD is related to destabilization of mushroom postsynaptic …
Novel loci and pathways significantly associated with longevity
Only two genome-wide significant loci associated with longevity have been identified so far,
probably because of insufficient sample sizes of centenarians, whose genomes may harbor …
probably because of insufficient sample sizes of centenarians, whose genomes may harbor …
Post-translational remodeling of ryanodine receptor induces calcium leak leading to Alzheimer's disease-like pathologies and cognitive deficits
A Lacampagne, X Liu, S Reiken, R Bussiere… - Acta …, 2017 - Springer
The mechanisms underlying ryanodine receptor (RyR) dysfunction associated with
Alzheimer disease (AD) are still not well understood. Here, we show that neuronal RyR2 …
Alzheimer disease (AD) are still not well understood. Here, we show that neuronal RyR2 …
Store-operated calcium channel complex in postsynaptic spines: a new therapeutic target for Alzheimer's disease treatment
H Zhang, S Sun, L Wu, E Pchitskaya… - Journal of …, 2016 - Soc Neuroscience
Mushroom dendritic spine structures are essential for memory storage and the loss of
mushroom spines may explain memory defects in aging and Alzheimer9s disease (AD). The …
mushroom spines may explain memory defects in aging and Alzheimer9s disease (AD). The …
Role of BDNF/ProBDNF imbalance in postoperative cognitive dysfunction by modulating synaptic plasticity in aged mice
Z Xue, M Shui, X Lin, Y Sun, J Liu, C Wei… - Frontiers in Aging …, 2022 - frontiersin.org
Postoperative cognitive dysfunction (POCD) is a disturbing neurological complication in
patients undergoing anesthesia and surgical procedures. Brain-derived neurotrophic factor …
patients undergoing anesthesia and surgical procedures. Brain-derived neurotrophic factor …
Small molecule modulator of sigma 2 receptor is neuroprotective and reduces cognitive deficits and neuroinflammation in experimental models of Alzheimer's disease
B Yi, JJ Sahn, PM Ardestani, AK Evans… - Journal of …, 2017 - Wiley Online Library
Accumulating evidence suggests that modulating the sigma 2 receptor (Sig2R) can provide
beneficial effects for neurodegenerative diseases. Herein, we report the identification of a …
beneficial effects for neurodegenerative diseases. Herein, we report the identification of a …
On the role of store-operated calcium entry in acute and chronic neurodegenerative diseases
In both excitable and non-excitable cells, calcium (Ca2+) signals are maintained by a highly
integrated process involving store-operated Ca2+ entry (SOCE), namely the opening of …
integrated process involving store-operated Ca2+ entry (SOCE), namely the opening of …