Gastric cancer (GC) represents an important contributor to the global burden of cancer,
being one of the most common and deadly malignancies worldwide. According to TCGA and …

Gastric cancer is one of the most common malignancies and remains the second leading
cause of cancer-related death worldwide. Over 70% of new cases and deaths occur in …

Abstract 'Epigenetics' is defined as the inheritable changes in gene expression with no
alterations in DNA sequences. Epigenetics is a rapidly expanding field, and the study of …

Epigenetic gene inactivation plays a key role in the development of various types of cancer.
Using methylated CpG island amplification coupled with representational difference analysis …

In the yeast Saccharomyces cerevisiae, the Rad6–Rad18 DNA damage tolerance pathway
constitutes a major defense system against replication fork blocking DNA lesions. The Rad6 …

Chronic colonization of the human stomach by Helicobacter pylori, a Gram-negative
bacterium, is the major cause of chronic gastritis, peptic ulcers and gastric cancer. Recent …

Transcriptional silencing by CpG island hypermethylation is a potential mechanism for the
inactivation of tumor-related genes. Virtually, all types of human cancers show CpG island …

Background & Objectives: Chromatin structure is the single most important feature that
distinguishes a cancer cell from a normal cell histologically. Chromatin remodeling proteins …

In gastric cancer (GC) the loss of genomic stability represents a key molecular step that
occurs early in the carcinogenesis process and creates a permissive environment for the …

Purpose: Gastric cancer is a curable disease if diagnosed at early stage. However, most
cases are diagnosed at advanced stage because of the lack of screening programs …