Merkel cell carcinoma is a skin cancer often driven by Merkel cell polyomavirus (MCPyV)
with high rates of response to anti-PD-1 therapy despite low mutational burden. MCPyV …

Early in solid tumor development, antigens are presented in tumor-draining lymph nodes
(tdLNs), a process that is necessary to set up immune surveillance. Recent evidence …

Since its introduction into the field of oncology, deep learning (DL) has impacted clinical
discoveries and biomarker predictions. DL-driven discoveries and predictions in oncology …

Bladder cancer, a common malignancy of the urinary system, is routinely treated with
radiation, chemotherapy, and surgical excision. However, these strategies have inherent …

The emergence of immunotherapy has revolutionized the traditional treatment paradigm of
colorectal cancer (CRC). Among them, immune checkpoint blockade has become the first …

Abstract IL-10+ regulatory B cells (Bregs) play a significant role in cancer immunotherapy
and their presence is an indicator of negative outcome. We found that PPARδ is significantly …

Background The low response rate of immune checkpoint inhibitors (ICIs) prompts the
exploration of novel combination therapies for patients with hepatocellular carcinoma …

The immune system defines a complex network of tissues and cell types that orchestrate
responses across the body in a dynamic manner. The local and systemic interactions …

Recent advances in immunotherapy have affirmed the curative potential of T cell-based
approaches for treating relapsed and refractory cancers. However, the therapeutic efficacy is …

Lymph node metastasis (LNM) significantly impacts the prognosis of cancer patients.
Despite significant advancements in diagnostic techniques and treatment modalities, clinical …