Cadmium (Cd) is a toxic metal for the human organism and for all ecosystems. Cd is
naturally found at low levels; however, higher amounts of Cd in the environment result from …

Lynch syndrome, which is now recognized as the most common hereditary colorectal cancer
condition, is characterized by the predisposition to a spectrum of cancers, primarily …

Three processes act in series to accurately replicate the eukaryotic nuclear genome. The
major replicative DNA polymerases strongly prevent mismatch formation, occasional …

DNA damage has been long recognized as causal factor for cancer development. When
erroneous DNA repair leads to mutations or chromosomal aberrations affecting oncogenes …

This review discusses the role of DNA mismatch repair (MMR) in the DNA damage response
(DDR) that triggers cell cycle arrest and, in some cases, apoptosis. Although the focus is on …

Antibiotic resistance is often the result of mutations that block drug activity; however, bacteria
also evade antibiotics by transiently expressing genes such as multidrug efflux pumps. A …

Colorectal cancer (CRC) is a heterogeneous disease that is caused by the interaction of
genetic and environmental factors. Although it is one of the most common cancers …

Cancer chemotherapy and radiotherapy are designed to kill cancer cells mostly by inducing
DNA damage. DNA damage is normally recognized and repaired by the intrinsic DNA …

The risk assessment of chemical carcinogens is one major task in toxicology. Even though
exposure has been mitigated effectively during the last decades, low levels of carcinogenic …

Lynch syndrome (LS) is characterised by predisposition to colorectal, endometrial, and other
cancers and is caused by inherited pathogenic variants affecting the DNA mismatch repair …