Background: The Religious Orders Study and Rush Memory and Aging Project are both
ongoing longitudinal clinical-pathologic cohort studies of aging and Alzheimer's disease …

Recent epidemiological and clinico-pathological data indicate considerable overlap
between cerebrovascular disease (CVD) and Alzheimer's disease (AD) and suggest …

In this review, we focus on the potential role of the γ-aminobutyric acidergic (GABAergic)
system in age-related episodic memory impairments in humans, with a particular focus on …

Introduction White matter hyperintensities (WMH) are often described in Alzheimer's disease
(AD), but their topography and specific relationships with cognition remain unclear. Methods …

Vascular cognitive impairment describes a continuum of cognitive diorders ranging from
mild cognitive impairment to dementia, in which vascular brain injury involving regions …

Our primary objective was to investigate a biomarker driven model for the interrelationships
between vascular disease pathology, amyloid pathology, and longitudinal cognitive decline …

Introduction This article reviews the work done in the Alzheimer's Disease Neuroimaging
Initiative positron emission tomography (ADNI PET) core over the past 5 years, largely …

Chromosome 21, triplicated in Down Syndrome, contains several genes that are thought to
play a critical role in the development of AD neuropathology. The overexpression of the …

Abstract Introduction The Alzheimer's Disease Neuroimaging Initiative (ADNI) was
established in 2004 to facilitate the development of effective treatments for Alzheimer's …

Accumulating evidence implicates small vessel cerebrovascular disease, visualized as
white matter hyperintensities (WMH) on T2-weighted magnetic resonance imaging, in the …