ABC transporters are essential for cellular physiology. Humans have 48 ABC genes
organized into seven distinct families. Of these genes, 44 (in five distinct families) encode for …

A repertoire of transporters plays a crucial role in maintaining homeostasis of biologically
essential transition metals, manganese, and iron, thus ensuring cell viability. Elucidating the …

In eukaryotes, iron-sulfur clusters are essential cofactors for numerous physiological
processes, but these clusters are primarily biosynthesized in mitochondria. Previous studies …

Multidrug resistance-associated protein 4 (MRP4) is an ATP-binding cassette (ABC)
transporter expressed at multiple tissue barriers where it actively extrudes a wide variety of …

Electron cryomicroscopy (cryoEM) has made great strides in the last decade, such that the
atomic structure of most biological macromolecules can, at least in principle, be determined …

Human ATP-binding cassette (ABC) transporters are one of the largest families of
membrane proteins and perform diverse functions. Many of them are associated with …

While mechanosensitive ion channels' gating has been well documented, the effect of
membrane mechanics, in particular membrane curvature, on the function of transporters …

Iron-sulfur (Fe-S) clusters are ubiquitous inorganic cofactors required for numerous essential
cellular pathways. Since they cannot be scavenged from the environment, Fe-S clusters are …