Background New drugs and new evidence concerning the use of established treatments
have become available since the publication of the first European League Against …

Allergists and clinical immunologists around the world are increasingly faced with the task of
addressing drug allergy and hypersensitivity due to the increase in drug reactions …

This article has been corrected. The original version (PDF) is appended to this article as a
Supplement. Description: The American College of Physicians (ACP) and the American …

Description: The American College of Physicians (ACP) developed this guideline to present
the evidence and provide clinical recommendations on the management of gout. Methods …

Introduction: Urate-lowering therapy (ULT) is the cornerstone of gout management, which is
a widespread chronic illness characterized by hyperuricemia, arthropathy, tophus …

Uric acid is the final oxidation product of purine metabolism in humans. Xanthine
oxidoreductase (XOR) catalyzes oxidative hydroxylation of hypoxanthine to xanthine to uric …

Uric acid (UA) is the end product of purine metabolism, and its concentration in blood can
increase in humans, great apes, and dalmatian dogs as a consequence of a genetic …

Objective To evaluate the use of prospective screening for the HLA-B* 58: 01 allele to
identify Taiwanese individuals at risk of severe cutaneous adverse reactions (SCARs) …

Objective Allopurinol, an antihyperuricaemic agent, is one of the common causes of life-
threatening severe cutaneous adverse reactions (SCAR), including drug rash with …

Allopurinol is the most commonly prescribed urate-lowering therapy for the management of
gout. Serious adverse reactions associated with allopurinol, while rare, are feared owing to …