The science of uncertainty guides fetal-neonatal neurology principles and practice: diagnostic-prognostic opportunities and challenges

MS Scher - Frontiers in Neurology, 2024 - frontiersin.org
Fetal-neonatal neurologists (FNNs) consider diagnostic, therapeutic, and prognostic
decisions strengthened by interdisciplinary collaborations. Bio-social perspectives of the …

The hope, hype and obstacles surrounding cell therapy

C Tręda, A Włodarczyk, P Rieske - Journal of Cellular and …, 2024 - Wiley Online Library
Cell therapy offers hope, but it also presents challenges, most particularly the limited ability
of human organs and tissues to regenerate. Since many diseases are associated with …

Congenital brain malformations-update on newer classification and genetic basis

A Sarma, S Pruthi - Seminars in Roentgenology, 2023 - Elsevier
Congenital malformations of the brain are caused by disruption of normal development
during embryonic or fetal life and are present from birth. Increasing investigation of the …

Sample Preparation Method for MALDI Mass Spectrometry Imaging of Fresh-Frozen Spines

KJ Bender, Y Wang, CY Zhai, Z Saenz… - Analytical …, 2023 - ACS Publications
Technologies assessing the lipidomics, genomics, epigenomics, transcriptomics, and
proteomics of tissue samples at single-cell resolution have deepened our understanding of …

Zinc oxide nanoparticles induces cell death and consequently leading to incomplete neural tube closure through oxidative stress during embryogenesis

Y Yan, W Huang, X Lu, X Chen, Y Shan, X Luo… - Cell Biology and …, 2024 - Springer
The implementation of Zinc oxide nanoparticles (ZnO NPs) raises concerns regarding their
potential toxic effects on human health. Although more and more researches have confirmed …

Molecular landscape of congenital vertebral malformations: recent discoveries and future directions

A Szoszkiewicz, E Bukowska-Olech… - Orphanet Journal of Rare …, 2024 - Springer
Vertebral malformations (VMs) pose a significant global health problem, causing chronic
pain and disability. Vertebral defects occur as isolated conditions or within the spectrum of …

Multidisciplinary management of children with occult spinal dysraphism: A comprehensive journey from birth to adulthood

IG Vetrano, A Barbotti, A Erbetta, S Mariani, SM Bova… - Children, 2022 - mdpi.com
Occult spinal dysraphism (OSD) comprises different forms of failure in embryogenic
development that can lead to genitourinary, spinal, or lower limb alterations, thus …

Online healthcare transition resources for pediatric neurosurgical care: supporting the journey of individuals living with spina bifida

A Malhotra, MM Locastro, H Castillo… - Neurosurgical …, 2024 - thejns.org
OBJECTIVE In the global environment in which neurosurgical providers practice, there is a
pressing need to identify and highlight online resources to support families shifting from …

Stem Cell-Based Strategies for Prenatal Treatment of Spina Bifida and the Promise of Cell-Free, Minimally Invasive Approaches

B Corradetti, F Taraballi, RH Finnell - Current Stem Cell Reports, 2024 - Springer
Abstract Purpose of Review Spina bifida (SB) is a severe birth defect that affects 1400
newborns annually in the USA. SB is often diagnosed before irreversible neurological …

Differences between Myeloschisis and Myelomeningocele in patients undergoing prenatal repair of Open Spina Bifida

JM Müller, EC Sereño, A Jimenez, R Zapata… - Fetal Diagnosis and …, 2024 - karger.com
Introduction: Open spina bifida (OSB) manifests as myelomeningocele (MMC) or
myeloschisis (MS). Both lesions theoretically leak cerebrospinal fluid (CSF) and produce …