Hyperbilirubinemia is the most frequent clinical problem neonatologists must deal with
during the newborn period. It has been suggested that bilirubin is involved in the balance …

Objectives: Oxidative stress and inflammation induce the expression of heme oxygenase-1,
which produces carbon monoxide (CO), and nitric oxide synthase, which produces nitric …

Heme oxygenase (HO), a catabolic enzyme, provides the rate‐limiting step in the oxidative
breakdown of heme, to generate carbon monoxide (CO), iron, and biliverdin‐IXα. Induction …

Intestinal ischemia-reperfusion has been implicated in the systemic inflammatory response
and organ injury in hemorrhagic shock, but the exact role of the intestine has never been …

Heme oxygenase-1 (HO-1) catalyzes the regiospecific oxidative degradation of heme to
biliverdin IXα, iron, and carbon monoxide. Biliverdin IXα is subsequently reduced to bilirubin …

Heme oxygenase (HO) is considered to be an antioxidant enzyme that catabolizes heme to
produce carbon monoxide (CO) and biliverdin. We determined the expression and …

The lungs are the richest in oxygen among the various organs of the body and are always
subject to harmful reactive oxygen species. Regulation of the reduction/oxidation (redox) …

To identify molecular events occurring during the early response to hyperoxia, we measured
changes over time in total lung gene expression in C57BL/6 mice during prolonged …

Heme oxygenase‐1 (HO‐1) is a regulated enzyme induced in multiple stress states. Carbon
monoxide (CO) is a product of HO catalysis of heme. In many circumstances, CO appears to …

Many effector functions of nitrogen monoxide (NO) and carbon monoxide (CO) are mediated
through their high-affinity for iron (Fe). In this review, the roles of NO and CO are examined …