[HTML][HTML] Aerobic exercise improves motor dysfunction in Parkinson's model mice via differential regulation of striatal medium spiny neuron

Y Wang, L Wei, M Tan, Z Yang, B Gao, J Li, Y Liu… - Scientific Reports, 2024 - nature.com
The striatum plays a crucial role in providing input to the basal ganglia circuit and is
implicated in the pathological process of Parkinson's disease (PD). Disruption of the …

[HTML][HTML] Green Synthesis of Silver Nanoparticles with Extracts from Kalanchoe fedtschenkoi: Characterization and Bioactivities

JL Mejía-Méndez, G Sánchez-Ante, M Cerro-López… - Biomolecules, 2024 - mdpi.com
In this work, the hexane, chloroform, and methanol extracts from Kalanchoe fedtschenkoi
were utilized to green-synthesize silver nanoparticles (Kf1-, Kf2-, and Kf3-AgNPs). The Kf1 …

[HTML][HTML] Postbiotics as Molecules Targeting Cellular Events of Aging Brain—The Role in Pathogenesis, Prophylaxis and Treatment of Neurodegenerative Diseases

P Głowacka, K Oszajca, A Pudlarz, J Szemraj… - Nutrients, 2024 - mdpi.com
Aging is the most prominent risk factor for neurodegeneration occurrence. The most
common neurodegenerative diseases (NDs), Alzheimer's (AD) and Parkinson's (PD) …

Systematic genome-wide Mendelian randomization reveals the causal links between miRNAs and Parkinson's disease

G Shi, T Wu, X Li, D Zhao, Q Yin, L Zhu - Frontiers in Neuroscience, 2024 - frontiersin.org
Background MicroRNAs (miRNAs) have pivotal roles in gene regulation. Circulating
miRNAs have been developed as novel candidate non-invasive biomarkers for diagnosis …

The Vital Role of Melatonin and Its Metabolites in the Neuroprotection and Retardation of Brain Aging

G Bocheva, D Bakalov, P Iliev… - International Journal of …, 2024 - mdpi.com
While primarily produced in the pineal gland, melatonin's influence goes beyond its well-
known role in regulating sleep, nighttime metabolism, and circadian rhythms, in the field of …

[HTML][HTML] The Therapeutic Potential of Harpagophytum procumbens and Turnera subulata and Advances in Nutraceutical Delivery Systems in Neurodegenerative …

AC Vital Júnior, MB da Silva, SS Monteiro… - Pharmaceuticals, 2024 - mdpi.com
This review article covers the therapeutic potential of the plants Harpagophytum
procumbens and Turnera subulata in the treatment of neurodegenerative diseases. Despite …

Therapeutic potential of Aloe vera-coated curcumin encapsulated nanoparticles in an Alzheimer-induced mice model: behavioural, biochemical and histopathological …

P Sharma, P Kumari, M Sharma, R Sharma… - Journal of …, 2024 - Taylor & Francis
Objective The main purpose of the present study was to evaluate the therapeutic efficacy of
Aloe vera-coated curcumin encapsulated nanoparticles in mitigating Alzheimer's disease …

[HTML][HTML] Alzheimer's disease and drug delivery across the blood–brain barrier: approaches and challenges

I Iqbal, F Saqib, Z Mubarak, MF Latif, M Wahid… - European Journal of …, 2024 - Springer
Alzheimer's disease (AD) is a diverse disease with a complex pathophysiology. The
presence of extracellular β-amyloid deposition as neuritic plaques and intracellular …

[HTML][HTML] Melatonin and Cytokines Modulate Daily Instrumental Activities of Elderly People with SARS-CoV-2 Infection

DCH França, M Fujimori, AA de Queiroz… - International Journal of …, 2023 - mdpi.com
The Comprehensive Geriatric Assessment analyzes the health and quality of life of the
elderly. Basic and instrumental daily activities may be compromised due to …

[HTML][HTML] Changes in the Secretion of Melatonin and Selected Adipokines during the Progression of Parkinson's Disease—Preliminary Studies

J Milanowski, K Kozerawski, W Falęcka, D Dudek… - Metabolites, 2023 - mdpi.com
Parkinson's disease (PD) is one of the most common neurodegenerative diseases affecting
elderly people. Considering the gap in the literature on melatonin and adipokine levels in …