Ferroptosis is a mechanism of regulated necrotic cell death characterized by iron-
dependent, lipid peroxidation-driven membrane destruction that can be inhibited by …

Iron is an essential element that is indispensable for life. The delicate physiological body
iron balance is maintained by both systemic and cellular regulatory mechanisms. The iron …

Acute kidney injury (AKI) is a heterogeneous group of critical disease conditions with high
incidence and mortality. Vasoconstriction, oxidative stress, apoptosis, and inflammation are …

Acute and chronic kidney injuries result from structural dysfunction and metabolic disorders
of the kidney in various etiologies, which significantly affect human survival and social …

Background and Purpose Acute kidney injury is a common clinical problem with no definitive
or specific treatment. Therefore, the molecular mechanisms of acute kidney injury must be …

Chemotherapeutic drug-induced acute kidney injury (AKI) involves pathologically increased
labile iron species in the kidneys that mediate the excessive generation of reactive oxygen …

Ferroptosis, a novel form of regulated cell death, is characterized by imbalance of
intracellular iron and redox systems, resulting from overgeneration of toxic lipid peroxidation …

The kidney is a crucial organ that eliminates metabolic waste and reabsorbs nutritious
elements. It also participates in the regulation of blood pressure, maintenance of electrolyte …

Folic acid (FA)-induced acute kidney injury (AKI) is characterized by the disturbance of redox
homeostasis, resulting in massive tubular necrosis and inflammation. Α-lipoic acid (LA), as …

Iron is a trace element necessary for cell growth, development, and cellular homeostasis, but
insufficient or excessive level of iron is toxic. Intracellularly, sufficient amounts of iron are …