Chemotherapeutic drug-induced acute kidney injury (AKI) involves pathologically increased
labile iron species in the kidneys that mediate the excessive generation of reactive oxygen …

Iron is a trace element necessary for cell growth, development, and cellular homeostasis, but
insufficient or excessive level of iron is toxic. Intracellularly, sufficient amounts of iron are …

Regulation of body fluid homeostasis is a major renal function, occurring largely through
epithelial solute transport in various nephron segments driven by Na+/K+-ATPase activity …

Renal I/R injury is a severe medical condition contributing to acute kidney injury (AKI),
leading to rapid kidney dysfunction and high mortality rates. It is generally observed during …

Ferroptosis is a form of iron-dependent, non-apoptotic regulated cell death, which is
characterized by the accumulation of lipid hydroperoxides to lethal levels. Ferroptosis …

Multifaceted cellular pathways exhibit a crucial role in the preservation of homeostasis at the
molecular, cellular, and organism levels. One of the most important of these protective …

Acute kidney injury (AKI) is a very common condition with high morbidity and mortality, which
can be seen in 5–7% of all hospitalized patients and in up to 57% of all intensive care unit …

Systemic lupus erythematosus (SLE) is an autoimmune disease that is accompanied with
autoantibody production and inflammation. Other features of SLE pathogenesis include iron …

In addition to the known prominent role of polyunsaturated (phospho) lipids as structural
blocks of biomembranes, there is an emerging understanding of another important function …

The transmembrane protein SLC22A17 [or the neutrophil gelatinase-associated
lipocalin/lipocalin-2 (LCN2)/24p3 receptor] is an atypical member of the SLC22 family of …