The gastrointestinal (GI) barrier serves a critical role in survival and overall health of animals
and humans. Several layers of barrier defense mechanisms are provided by the epithelial …

Neonates have an immature immune system, which cannot adequately protect against
infectious diseases. Early in life, immune protection is accomplished by maternal antibodies …

An animal model to study human infectious diseases should accurately reproduce the
various aspects of disease. Domestic pigs (Sus scrofa domesticus) are closely related to …

The intestinal epithelial monolayer forms a transcellular and paracellular barrier that
separates luminal contents from the interstitium. The paracellular barrier consists of a highly …

Ongoing challenges in the swine industry, such as reduced access to antibiotics and virus
outbreaks (eg, porcine epidemic diarrhea virus, African swine fever virus), have prompted …

Medium-chain fatty acids (MCFAs) are found at higher levels in milk lipids of many animal
species and in the oil fraction of several plants, including coconuts, palm kernels and certain …

Over the last few years, we have seen an increasing interest and demand for pigs in
biomedical research. Domestic pigs (Sus scrofa domesticus) are closely related to humans …

How fish larvae are protected from infection before the maturation of adaptive immunity, a
process which may take up to several weeks in most species, has long been a matter of …

Relevance. The immune response to gut antigens is initiated in the organized gut-
associated lymphoid tissue, which regulates its specificity and modulates the gut microbiota …

Animal experimentation is necessary to characterize human diseases and design adequate
therapeutic interventions. In renal transplantation research, the limited number of in vitro …