Inorganic nanomaterials with rapid clearance for biomedical applications

X Wang, X Zhong, J Li, Z Liu, L Cheng - Chemical Society Reviews, 2021 - pubs.rsc.org
Inorganic nanomaterials that have inherently exceptional physicochemical properties (eg,
catalytic, optical, thermal, electrical, or magnetic performance) that can provide desirable …

[HTML][HTML] DNA damage response signaling pathways and targets for radiotherapy sensitization in cancer

RX Huang, PK Zhou - Signal transduction and targeted therapy, 2020 - nature.com
Radiotherapy is one of the most common countermeasures for treating a wide range of
tumors. However, the radioresistance of cancer cells is still a major limitation for …

The role of ferroptosis in ionizing radiation-induced cell death and tumor suppression

G Lei, Y Zhang, P Koppula, X Liu, J Zhang, SH Lin… - Cell research, 2020 - nature.com
Ferroptosis, a form of regulated cell death caused by lipid peroxidation, was recently
identified as a natural tumor suppression mechanism. Here, we show that ionizing radiation …

Inflammatory microenvironment remodelling by tumour cells after radiotherapy

M McLaughlin, EC Patin, M Pedersen, A Wilkins… - Nature Reviews …, 2020 - nature.com
The development of immune checkpoint inhibitors (ICIs) is revolutionizing the way we think
about cancer treatment. Even so, for most types of cancer, only a minority of patients …

Artificial intelligence in radiation oncology

E Huynh, A Hosny, C Guthier, DS Bitterman… - Nature Reviews …, 2020 - nature.com
Artificial intelligence (AI) has the potential to fundamentally alter the way medicine is
practised. AI platforms excel in recognizing complex patterns in medical data and provide a …

Ferroptosis, radiotherapy, and combination therapeutic strategies

G Lei, C Mao, Y Yan, L Zhuang, B Gan - Protein & cell, 2021 - academic.oup.com
Ferroptosis, an iron-dependent form of regulated cell death driven by peroxidative damages
of polyunsaturated-fatty-acid-containing phospholipids in cellular membranes, has recently …

Advances and perspectives in organic sonosensitizers for sonodynamic therapy

X Xing, S Zhao, T Xu, L Huang, Y Zhang, M Lan… - Coordination Chemistry …, 2021 - Elsevier
Sonodynamic therapy (SDT), which involves a combination of low-intensity ultrasound (US)
and a chemical sonosensitizer, has emerged as a promising minimally invasive and …

Radiation therapy‐associated toxicity: Etiology, management, and prevention

K Wang, JE Tepper - CA: A Cancer Journal for Clinicians, 2021 - Wiley Online Library
Radiation therapy (RT) is a curative treatment for many malignancies and provides effective
palliation in patients with tumor‐related symptoms. However, the biophysical effects of RT …

ROS signalling in the biology of cancer

JN Moloney, TG Cotter - Seminars in cell & developmental biology, 2018 - Elsevier
Increased reactive oxygen species (ROS) production has been detected in various cancers
and has been shown to have several roles, for example, they can activate pro-tumourigenic …

Hypofractionated FLASH-RT as an Effective Treatment against Glioblastoma that Reduces Neurocognitive Side Effects in MiceSparing the Cognition, not the Tumor …

P Montay-Gruel, MM Acharya, P Gonçalves Jorge… - Clinical Cancer …, 2021 - AACR
Purpose: Recent data have shown that single-fraction irradiation delivered to the whole
brain in less than tenths of a second using FLASH radiotherapy (FLASH-RT), does not elicit …