Gram-positive bacterial infections are among the most serious diseases related with high
mortality rates and huge healthcare costs especially with the rise of antibiotic-resistant …

Background: Therapeutic drug monitoring (TDM) of anti-infective drugs is an increasingly
complex field, given that in addition to the patient and drug as 2 usual determinants, its …

Linezolid is an oxazolidinone antibacterial drug, and its therapeutic drug monitoring and
individualized treatment have been challenged since its approval. With the in-depth clinical …

Therapeutic drug monitoring (TDM) of antibiotics (ATB) in patients with serious bacterial
infections allows optimization of the efficacy of the treatment while reducing the risk of …

We read with great interest the Letter by Lee and colleagues describing proteome analysis
of a Mycobacterium tuberculosis strain that caused tuberculosis (TB) relapse in a young …

Quantification of beta-lactam antibiotics can be performed by using liquid chromatography in
combination with tandem mass spectrometry (MS/MS) or ultraviolet (UV) detection. Since …

Objectives Knowledge on the tissue penetration of piperacillin-tazobactam in children with
sepsis is lacking. In this study, the feasibility and performance of microdialysis experiments …

Background: Recently, several studies have assessed the effects of therapeutic drug
monitoring of frequently prescribed beta-lactam antibiotics, for which they were quantified in …

Introduction Ceftazidime is used for the treatment of many bacterial infections, including
severe P. aeruginosa infections. Like other beta-lactams, inter-individual variability in …

Combined prescription of the antimicrobial drugs linezolid and meropenem is a common
strategy to treat multidrug-resistant nosocomial infections. We propose an innovative method …