Immune checkpoint inhibitors targeting programmed cell death protein 1, programmed death-
ligand 1, and cytotoxic T-lymphocyte-associated protein 4 provide deep and durable …

Diabetic cardiomyopathy (DCM) is a chronic complication of diabetes mellitus, characterized
by abnormalities of myocardial structure and function. Researches on the models of type 1 …

Cancer is an important cause of death worldwide. The main types of cancer treatment are
still surgery, chemotherapy and radiotherapy, and immunotherapy is becoming an important …

Pyroptosis is a form of regulated cell death that is characterized by gasdermin processing
and increased membrane permeability. Caspase-1 and caspase-11 have been considered …

Although combined antiretroviral therapy (cART) is effective in inhibiting human
immunodeficiency virus type 1 (HIV-1) replication, it does not eradicate the virus because …

Inflammation is a key characteristic of all stages of tumor development, including tumor
initiation, progression, malignant transformation, invasion, and metastasis. Inflammasomes …

Simple Summary Molecular target therapy, ie, antiangiogenesis with bevacizumab, was
found to be effective in some patients of epithelial ovarian cancer. Considering the cost …

Chemotherapy drugs usually inhibit tumor cell growth through the apoptosis pathway.
However, tumor cells become resistant to chemotherapy drugs by evading apoptosis. It is …

The tumor matrix together with inflammation and autophagy are crucial regulators of cancer
development. Embedded in the tumor stroma are numerous proteoglycans which, in their …

NLRP1 (NLR family, pyrin domain containing 1), the first NLR protein, described to form an
inflammasome, plays critical roles in innate immunity and inflammation. However, NLRP1 …