Proteomic insights into SARS-CoV-2 infection mechanisms, diagnosis, therapies and prognostic monitoring methods

S Yu, X Li, Z Xin, L Sun, J Shi - Frontiers in Immunology, 2022 - frontiersin.org
At the end of 2019, the COVID-19 pandemic, caused by severe acute respiratory syndrome
coronavirus type 2 (SARS-CoV-2) infection, seriously damaged world public health security …

Discovery of potential therapeutic drugs for covid-19 through logistic matrix factorization with kernel diffusion

X Tian, L Shen, P Gao, L Huang, G Liu, L Zhou… - Frontiers in …, 2022 - frontiersin.org
Coronavirus disease 2019 (COVID-19) is rapidly spreading. Researchers around the world
are dedicated to finding the treatment clues for COVID-19. Drug repositioning, as a rapid …

Analyzing host-viral interactome of SARS-CoV-2 for identifying vulnerable host proteins during COVID-19 pathogenesis

JK Das, S Roy, PH Guzzi - Infection, Genetics and Evolution, 2021 - Elsevier
The development of therapeutic targets for COVID-19 relies on understanding the molecular
mechanism of pathogenesis. Identifying genes or proteins involved in the infection …

SARS-CoV-2 ORF8 dimerization and binding mode analysis with class I MHC: computational approaches to identify COVID-19 inhibitors

C Selvaraj, DC Dinesh, EM Pedone… - Briefings in …, 2023 - academic.oup.com
SARS-CoV-2 encodes eight accessory proteins, one of which, ORF8, has a poorly
conserved sequence with SARS-CoV and its role in viral pathogenicity has recently been …

[HTML][HTML] Gene signatures and potential therapeutic targets of Middle East respiratory syndrome coronavirus (MERS-CoV)-infected human lung adenocarcinoma …

YH Wu, IJ Yeh, NN Phan, MC Yen, JH Hung… - Journal of Microbiology …, 2021 - Elsevier
Abstract Background Pathogenic coronaviruses include Middle East respiratory syndrome
coronavirus (MERS-CoV), severe acute respiratory syndrome coronavirus (SARS-CoV), and …

Natural products database screening for the discovery of naturally occurring SARS‐Cov‐2 spike glycoprotein blockers

AG Al‐Sehemi, FA Olotu, S Dev, M Pannipara… - …, 2020 - Wiley Online Library
SARS‐CoV‐2 coronavirus has been recognized the causative agent of the recent and
ongoing pandemic. Effective and specific antiviral agents or vaccines are still missing …

DRaW: prediction of COVID-19 antivirals by deep learning—an objection on using matrix factorization

SM Hashemi, A Zabihian, M Hooshmand… - BMC …, 2023 - Springer
Background Due to the high resource consumption of introducing a new drug, drug
repurposing plays an essential role in drug discovery. To do this, researchers examine the …

Essential interpretations of bioinformatics in COVID-19 pandemic

M Ray, MN Sable, S Sarkar, V Hallur - Meta Gene, 2021 - Elsevier
The currently emerging pathogen SARS-CoV-2 has produced the global pandemic crisis by
causing COVID-19. The unique and novel genetic makeup of SARS-CoV-2 has created …

IBD systems biology is here to stay

C Fiocchi, D Iliopoulos - Inflammatory bowel diseases, 2021 - academic.oup.com
Background Systems biology is a rapidly advancing field of science that allows us to look
into disease mechanisms, patient diagnosis and stratification, and drug development in a …

Present and future treatment strategies for coronavirus disease 2019

E Elekhnawy, AA Kamar, F Sonbol - Future journal of pharmaceutical …, 2021 - Springer
Background The recent pandemic of coronavirus disease 2019 (COVID-19) has resulted in
many challenges to the healthcare organizations around the world. Unfortunately, until now …